1-(2,6-dichloro-4-methoxyphenyl)-2-(2-fluoro-4-methoxyphenyl)ethene

Base Information

• Chemical Name: 1-(2,6-dichloro-4-methoxyphenyl)-2-(2-fluoro-4-methoxyphenyl)ethene
• CAS No.: 128412-96-4
• Molecular Formula: C₁₆H₁₃Cl₂FO₂
• Molecular Weight: 327.182
• Mol file: 128412-96-4.mol

Synonyms:1-(2,6-dichloro-4-methoxyphenyl)-2-(2-fluoro-4-methoxyphenyl)ethene

Chemical Property of 1-(2,6-dichloro-4-methoxyphenyl)-2-(2-fluoro-4-methoxyphenyl)ethene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,6-dichloro-4-methoxyphenyl)-2-(2-fluoro-4-methoxyphenyl)ethene

There total 1 articles about 1-(2,6-dichloro-4-methoxyphenyl)-2-(2-fluoro-4-methoxyphenyl)ethene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-dichloro-4-methoxy-benzaldehyde (82772-93-8) + 2-fluoro-4-methoxybenzyltriphenylphosphonium chloride → 1-(2,6-dichloro-4-methoxyphenyl)-2-(2-fluoro-4-methoxyphenyl)ethene (128412-96-4)

Guidance literature:

With ethanol; sodium; Multistep reaction; 1.) 30 min, 2.) 1 h;

DOI:10.1021/jm00171a031

Reference yield: 98.0%

1-(2,6-dichloro-4-methoxyphenyl)-2-(2-fluoro-4-methoxyphenyl)ethene (128412-96-4) → 1,3-Dichloro-2-[2-(2-fluoro-4-methoxy-phenyl)-ethyl]-5-methoxy-benzene

Guidance literature:

With hydrogen; palladium on activated charcoal; In benzene; for 48h; under 15001.2 Torr;

DOI:10.1002/1521-4184(200104)334:4<125::AID-ARDP125>3.0.CO;2-D

Reference yield:

1-(2,6-dichloro-4-methoxyphenyl)-2-(2-fluoro-4-methoxyphenyl)ethene (128412-96-4) → 3,5-Dichloro-4-[2-(2-fluoro-4-hydroxy-phenyl)-ethyl]-phenol

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / H₂ / 10 percent Pd/C / benzene / 48 h / 15001.2 Torr

2: 77 percent / BBr₃ / CH₂Cl₂

With hydrogen; boron tribromide; palladium on activated charcoal; In dichloromethane; benzene;

DOI:10.1002/1521-4184(200104)334:4<125::AID-ARDP125>3.0.CO;2-D

upstream raw materials:

2,6-dichloro-4-methoxy-benzaldehyde

Downstream raw materials:

3,5-Dichloro-4-[1,2-diamino-2-(2-fluoro-4-hydroxy-phenyl)-ethyl]-phenol

3,5-Dichloro-4-[1,2-diamino-2-(2-fluoro-4-hydroxy-phenyl)-ethyl]-phenol