82772-93-8

Basic information

• Product Name: 2,6-Dichloro-4-Methoxybenzaldehyde
• Synonyms: 2,6-Dichloro-4-Methoxybenzaldehyde;2,6-Dichloro-4-methyloxybenzaldehyde;Benzaldehyde, 2,6-dichloro-4-methoxy-
• CAS NO: 82772-93-8
• Molecular Formula: C₈H₆Cl₂O₂
• Molecular Weight: 205.03804
• Mol File: 82772-93-8.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2,6-Dichloro-4-Methoxybenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichloro-4-Methoxybenzaldehyde(82772-93-8)
• EPA Substance Registry System: 2,6-Dichloro-4-Methoxybenzaldehyde(82772-93-8)

Safety Data

• Hazardous Substances Data: 82772-93-8(Hazardous Substances Data)

Upstream product

• 86111-47-9 (2,6-dichloro-4-methoxy-phenyl)-methanol 
• 216257-25-9 3-chloro-5-[(triisopropylsilyl)oxy]phenyl chloride 
• 126663-61-4 1-<(tert-butyldimethylsilyl)oxy>-3,5-dichlorobenzene 
• 591-35-5 3,5-dichlorophenol 
• 60964-09-2 2,6-dichloro-4-hydroxybenzaldehyde 
• 74-88-4 methyl iodide 
• 59606-87-0 1,3-dichloro-2-(chloromethyl)-5-methoxybenzene 
• 33719-74-3 3,5-dichloroanisole 
• 50-00-0 formaldehyd 
• 4885-02-3 Dichloromethyl methyl ether 

Downstream Products

• 128412-96-4 1-(2,6-dichloro-4-methoxyphenyl)-2-(2-fluoro-4-methoxyphenyl)ethene 
• 128412-97-5 (E/Z)-1-(2-chloro-4-methoxyphenyl)-2-(2,6-dichloro-4-methoxyphenyl)ethene 
• 111086-59-0 d,l-1,2-bis-(2,6-dichlori-4-methoxyphenyl)ethylenediamine 
• 157487-25-7 trans-1,3-bis-(2,6-dichloro-4-methoxyphenyl)-2-propen-1-one 
• 82772-94-9 [1-(2,6-Dichloro-4-methoxy-phenyl)-meth-(Z)-ylidene]-methyl-amine 
• 82772-95-0 [1-(2,6-Dichloro-4-methoxy-phenyl)-meth-(Z)-ylidene]-ethyl-amine 
• 911718-18-8 2,4-dichloro-6-methoxybenzyl alcohol 
• 86111-47-9 (2,6-dichloro-4-methoxy-phenyl)-methanol 
• 955406-96-9 3-[2,6-Dichloro-4-(1-methyl-1H-pyrazol-4-yl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one 
• 955407-60-0 3,5-Dichloro-N-isobutyl-4-[2-oxo-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-3-ylmethyl]-benzamide 
• 955406-24-3 C₂₇H₂₄Cl₂F₃N₃O₅S 
• 30482-87-2 2,6-dichloro-4-methoxybenzonitrile 

Relevant articles and documents

2-(2-ACRYLOYL-2,6-DIAZASPIRO[3.4]OCTAN-6-YL)-6-(1H-INDAZOL-4-YL)-BENZONITRILE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF G12C MUTANT KRAS PROTEIN FOR INHIBITING TUMOR METASTASIS

The present invention provides e.g. 2-(2-acryloyl-2,6- diazaspiro[3.4]octan-6-yl)-6-(lH-indazol-4-yl)-benzonitrile and e.g. 2-(2-acryloyl-2,7-diazaspiro[3.5]nonan-7-yl)-6-(1H-indazol-4-yl)- benzonitrile derivatives and related compounds of formula (I) as inhibitors of G12C mutant KRAS protein for treating tumor metastasis. The present description discloses exemplary compounds (e.g. pages 53 to 90; table 1; compounds I-1 to I-141), pharmacological data (e.g. page 125 to 128; table 2; example 1) and synthesis thereof (e.g. pages 129 to 143; examples 2 to 7). Exemplary compounds are e.g. 2-(2-acryloyl-2,6- diazaspiro[3.4]octan-6-yl)-6-(5-methyl-1H-indazol-4-yl)-4- morpholinobenzonitrile (example 2; compound I-1) and 6-(2- acryloyl-2,7-diazaspiro[3.5]nonan-7-yl)-3-methoxy-2-(5-methyl-1H- indazol-4-yl)-4-morpholinobenzonitrile (example 7; compound I-84).

Synthesis of novel structurally simplified estrogen analogues with electron-donating groups in ring A

A library of 25 novel estrogen analogues were prepared in five to eight steps from mostly commercially available substituted anisoles via bromination, formylation, Corey-Fuchs reaction, elimination, and Sonogashira reaction. Georg Thieme Verlag Stuttgart.

CYCLOHEXYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1

The present invention discloses novel compounds of Formula I: having 11β -HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11β-HSD type 1 activity.