(-)-(2S,3R,4R)-1-(benzyloxy)-6,6-dimethoxy-3-methylhexane-2,4-diol

Base Information

Chemical Name:(-)-(2S,3R,4R)-1-(benzyloxy)-6,6-dimethoxy-3-methylhexane-2,4-diol
CAS No.:941295-51-8
Molecular Formula:C₁₆H₂₆O₅
Molecular Weight:298.379
Hs Code.:

Synonyms:(-)-(2S,3R,4R)-1-(benzyloxy)-6,6-dimethoxy-3-methylhexane-2,4-diol

Suppliers and Price of (-)-(2S,3R,4R)-1-(benzyloxy)-6,6-dimethoxy-3-methylhexane-2,4-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (-)-(2S,3R,4R)-1-(benzyloxy)-6,6-dimethoxy-3-methylhexane-2,4-diol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (-)-(2S,3R,4R)-1-(benzyloxy)-6,6-dimethoxy-3-methylhexane-2,4-diol

There total 12 articles about (-)-(2S,3R,4R)-1-(benzyloxy)-6,6-dimethoxy-3-methylhexane-2,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 941295-49-4
(+)-(R)-2-(benzyloxy)-1-[(2R,3R)-3-(2,2-dimethoxyethyl)oxiran-2-yl]ethanol

: 676-58-4
methylmagnesium chloride

: 941295-51-8
(-)-(2S,3R,4R)-1-(benzyloxy)-6,6-dimethoxy-3-methylhexane-2,4-diol

Guidance literature:: methylmagnesium chloride; With copper(l) chloride; In tetrahydrofuran; diethyl ether; at -20 ℃; for 0.5h;

(+)-(R)-2-(benzyloxy)-1-[(2R,3R)-3-(2,2-dimethoxyethyl)oxiran-2-yl]ethanol; In tetrahydrofuran; diethyl ether; at -40 - 20 ℃; for 4.33333h;

With sodium periodate; In acetonitrile; at 20 ℃; for 1h; Further stages.;
DOI:10.1021/ol070405p

Reference yield:

: 941295-58-5
1-(benzyloxy)-6,6-dimethoxyhex-3-yn-2-one

: 941295-51-8
(-)-(2S,3R,4R)-1-(benzyloxy)-6,6-dimethoxy-3-methylhexane-2,4-diol

Guidance literature:: Multi-step reaction with 4 steps

1.1: (S)-Alpine Borane / tetrahydrofuran / 96 h / 20 °C

2.1: i-BuMgBr / Cp₂TiCl₂ / diethyl ether / 0 - 20 °C

3.1: D-diethyl tartrate; tert-butyl hydroperoxide / Ti(Oi-Pr)4 / CH₂Cl₂; decane / 48 h / -20 °C

4.1: CuCl / tetrahydrofuran; diethyl ether / 0.5 h / -20 °C

4.2: tetrahydrofuran; diethyl ether / 4.33 h / -40 - 20 °C

With tert.-butylhydroperoxide; S-alpine borane; Diethyl tartrate; isobutylmagnesium bromide; copper(l) chloride; titanium(IV) isopropylate; bis(cyclopentadienyl)titanium dichloride; In tetrahydrofuran; diethyl ether; decane; dichloromethane; 3.1: Sharpless epoxidation;
DOI:10.1021/ol070405p

Reference yield:

: 941295-60-9
(+)-(S)-1-(benzyloxy)-6,6-dimethoxyhex-3-yn-2-ol

: 941295-51-8
(-)-(2S,3R,4R)-1-(benzyloxy)-6,6-dimethoxy-3-methylhexane-2,4-diol

Guidance literature:: Multi-step reaction with 3 steps

1.1: i-BuMgBr / Cp₂TiCl₂ / diethyl ether / 0 - 20 °C

2.1: D-diethyl tartrate; tert-butyl hydroperoxide / Ti(Oi-Pr)4 / CH₂Cl₂; decane / 48 h / -20 °C

3.1: CuCl / tetrahydrofuran; diethyl ether / 0.5 h / -20 °C

3.2: tetrahydrofuran; diethyl ether / 4.33 h / -40 - 20 °C

With tert.-butylhydroperoxide; Diethyl tartrate; isobutylmagnesium bromide; copper(l) chloride; titanium(IV) isopropylate; bis(cyclopentadienyl)titanium dichloride; In tetrahydrofuran; diethyl ether; decane; dichloromethane; 2.1: Sharpless epoxidation;
DOI:10.1021/ol070405p