(R/S)-2-hydroxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

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Chemical Name:(R/S)-2-hydroxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide
CAS No.:1344707-97-6
Molecular Formula:C₂₇H₂₇F₃N₆O₃
Molecular Weight:540.545
Hs Code.:

Synonyms:(R/S)-2-hydroxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

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Chemical Property of (R/S)-2-hydroxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

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Technology Process of (R/S)-2-hydroxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

There total 5 articles about (R/S)-2-hydroxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1344708-45-7
(R/S)-2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetic acid

: 51387-90-7,422545-96-8
2-(2-AMINOETHYL)-1-METHYLPYRROLIDINE

: 1344707-97-6
(R/S)-2-hydroxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Wheaton tubes;

Reference yield:

: 302912-31-8
ethyl-4-cyanobenzoylformate

: 1344707-97-6
(R/S)-2-hydroxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate; methanol / 1 h / 0 °C

2.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / isopropyl alcohol / 6 h / 70 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h

3.2: 2 h / 140 °C

3.3: 0.5 h

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.5 h

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C / Wheaton tubes

With methanol; sodium tetrahydroborate; hydroxylamine hydrochloride; water; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 847227-46-7
ethyl 2-(4-cyanophenyl)-2-hydroxyacetate

: 1344707-97-6
(R/S)-2-hydroxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / isopropyl alcohol / 6 h / 70 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h

2.2: 2 h / 140 °C

2.3: 0.5 h

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.5 h

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C / Wheaton tubes

With hydroxylamine hydrochloride; water; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; isopropyl alcohol;