C₂₂H₂₄N₄O₃

Base Information

• Chemical Name: C₂₂H₂₄N₄O₃
• CAS No.: 1309764-20-2
• Molecular Formula: C₂₂H₂₄N₄O₃
• Molecular Weight: 392.458
• Mol file: 1309764-20-2.mol

Synonyms:C₂₂H₂₄N₄O₃

Chemical Property of C₂₂H₂₄N₄O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₄N₄O₃

There total 7 articles about C₂₂H₂₄N₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H15BrN4O (1309764-45-1) + 2,5-dimethoxyphenylboronic acid (107099-99-0) → C22H24N4O3 (1309764-20-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; ethanol; water; at 90 ℃;

DOI:10.1016/j.bmc.2011.03.035

Reference yield:

4-amino-8-bromo-N-propyl-cinnoline-3-carboxamide (107346-32-7) → C22H24N4O3 (1309764-20-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sulfuric acid / water / 100 °C

2.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 2.25 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; ethanol; water / 90 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; potassium carbonate; 1,1'-carbonyldiimidazole; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; 3.1: Suzuki coupling;

DOI:10.1016/j.bmc.2011.03.035

Reference yield:

C8H12N2O → C22H24N4O3 (1309764-20-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride; acetic acid; sodium nitrite / water / 0 - 5 °C

1.2: -5 - 0 °C

2.1: aluminum (III) chloride / toluene / 70 - 90 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; ethanol; water / 90 °C

With hydrogenchloride; aluminum (III) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; acetic acid; sodium nitrite; In 1,2-dimethoxyethane; ethanol; water; toluene; 3.1: Suzuki coupling;

DOI:10.1016/j.bmc.2011.03.035

upstream raw materials:

4-amino-8-bromo-N-propyl-cinnoline-3-carboxamide

C₁₄H₁₅BrN₄O

2,5-dimethoxyphenylboronic acid

(E)-N-propyl-2-cyano-2-[(2-bromophenyl)hydrazono]acetamide