(2R,3R)-ethyl 1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-3-propylaziridine-2-carboxylate

Base Information

• Chemical Name: (2R,3R)-ethyl 1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-3-propylaziridine-2-carboxylate
• CAS No.: 1240306-07-3
• Molecular Formula: C₂₇H₃₇NO₄
• Molecular Weight: 439.595
• Mol file: 1240306-07-3.mol

Synonyms:(2R,3R)-ethyl 1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-3-propylaziridine-2-carboxylate

Chemical Property of (2R,3R)-ethyl 1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-3-propylaziridine-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R)-ethyl 1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-3-propylaziridine-2-carboxylate

There total 4 articles about (2R,3R)-ethyl 1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-3-propylaziridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

diazoacetic acid ethyl ester (623-73-4) + N-butylidene-1,1-bis(4-methoxy-3,5-dimethylphenyl)methanamine (1252653-28-3) → (2R,3R)-ethyl 1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-3-propylaziridine-2-carboxylate (1240306-07-3)

Guidance literature:

With C₅₂H₃₄B₃O₇^(1-)*H⁽¹⁺⁾; In toluene; at 25 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/jo101160c

Reference yield: 64.0%

diazoacetic acid ethyl ester (623-73-4) + N-butylidene-1,1-bis(4-methoxy-3,5-dimethylphenyl)methanamine (1252653-28-3) → C27H37NO4 + (2R,3R)-ethyl 1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-3-propylaziridine-2-carboxylate (1240306-07-3) + C27H37NO4

Guidance literature:

With C₅₂H₃₄B₃O₇^(1-)*H⁽¹⁺⁾; In toluene; at 25 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/jo101160c

Reference yield:

diazoacetic acid ethyl ester (623-73-4) + C19H25NO2*C52H34B3O7(1-)*H(1+) + butyraldehyde (123-72-8) → (2R,3R)-ethyl 1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-3-propylaziridine-2-carboxylate (1240306-07-3)

Guidance literature:

In toluene; at -10 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1021/ol202472z

upstream raw materials:

diazoacetic acid ethyl ester

N-butylidene-1,1-bis(4-methoxy-3,5-dimethylphenyl)methanamine

butyraldehyde

3,3',5,5'-tetramethyl-4,4'-dimethoxy benzhydrylamine