N-butylidene-1,1-bis(4-methoxy-3,5-dimethylphenyl)methanamine

Base Information

• Chemical Name: N-butylidene-1,1-bis(4-methoxy-3,5-dimethylphenyl)methanamine
• CAS No.: 1252653-28-3
• Molecular Formula: C₂₃H₃₁NO₂
• Molecular Weight: 353.505
• Mol file: 1252653-28-3.mol

Synonyms:N-butylidene-1,1-bis(4-methoxy-3,5-dimethylphenyl)methanamine

Chemical Property of N-butylidene-1,1-bis(4-methoxy-3,5-dimethylphenyl)methanamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-butylidene-1,1-bis(4-methoxy-3,5-dimethylphenyl)methanamine

There total 4 articles about N-butylidene-1,1-bis(4-methoxy-3,5-dimethylphenyl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3,3',5,5'-tetramethyl-4,4'-dimethoxy benzhydrylamine (1072879-54-9) + butyraldehyde (123-72-8) → N-butylidene-1,1-bis(4-methoxy-3,5-dimethylphenyl)methanamine (1252653-28-3)

Guidance literature:

In toluene; at 25 ℃; for 3h; Inert atmosphere; Molecular sieve;

DOI:10.1021/ja1070224

Reference yield:

diazoacetic acid ethyl ester (623-73-4) + C19H25NO2*C44H30B3O7(1-)*H(1+) + butyraldehyde (123-72-8) → N-butylidene-1,1-bis(4-methoxy-3,5-dimethylphenyl)methanamine (1252653-28-3) + C27H37NO2 + ethyl 1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-3-propylaziridine-2-carboxylate

Guidance literature:

In toluene; at 0 ℃; Inert atmosphere; Molecular sieve;

DOI:10.1021/ol202472z

Reference yield:

diazoacetic acid ethyl ester (623-73-4) + C19H25NO2*C44H30B3O7(1-)*H(1+) + butyraldehyde (123-72-8) → N-butylidene-1,1-bis(4-methoxy-3,5-dimethylphenyl)methanamine (1252653-28-3) + (2R,3R)-ethyl 1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-3-propylaziridine-2-carboxylate (1240306-08-4) + C27H37NO2

Guidance literature:

In toluene; at -30 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1021/ol202472z

upstream raw materials:

butyraldehyde

3,3',5,5'-tetramethyl-4,4'-dimethoxy benzhydrylamine

diazoacetic acid ethyl ester

Downstream raw materials:

(2R,3R)-ethyl 1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-3-propylaziridine-2-carboxylate

(2R,3R)-ethyl 1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-3-propylaziridine-2-carboxylate