4-[3-(2,6-Dichloro-phenyl)-5-trifluoromethyl-isoxazol-4-yl]-phenylamine

Base Information

Chemical Name:4-[3-(2,6-Dichloro-phenyl)-5-trifluoromethyl-isoxazol-4-yl]-phenylamine
CAS No.:122247-17-0
Molecular Formula:C₁₆H₉Cl₂F₃N₂O
Molecular Weight:373.161
Hs Code.:

Synonyms:4-[3-(2,6-Dichloro-phenyl)-5-trifluoromethyl-isoxazol-4-yl]-phenylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[3-(2,6-Dichloro-phenyl)-5-trifluoromethyl-isoxazol-4-yl]-phenylamine

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Technology Process of 4-[3-(2,6-Dichloro-phenyl)-5-trifluoromethyl-isoxazol-4-yl]-phenylamine

There total 3 articles about 4-[3-(2,6-Dichloro-phenyl)-5-trifluoromethyl-isoxazol-4-yl]-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 6579-27-7
2,6-dichlorobenzohydroximoyl chloride

: 122247-03-4
4-Trifluoroprop-1-ynyl-phenylamine

: 122247-17-0
4-[3-(2,6-Dichloro-phenyl)-5-trifluoromethyl-isoxazol-4-yl]-phenylamine

: 122247-10-3
4-[3-(2,6-Dichloro-phenyl)-4-trifluoromethyl-isoxazol-5-yl]-phenylamine

Guidance literature:: With triethylamine; In toluene; at 80 ℃; for 3h; Yields of byproduct given;
DOI:10.1055/s-1989-27247

Reference yield:

: 94812-54-1
1-(4-Aminophenyl)-2-chloro-3,3,3-trifluoropropene

: 122247-17-0
4-[3-(2,6-Dichloro-phenyl)-5-trifluoromethyl-isoxazol-4-yl]-phenylamine

Guidance literature:: Multi-step reaction with 2 steps

1: NaNH₂, t-BuOH / benzene; toluene / 1 h / Ambient temperature

2: Et₃N / toluene / 3 h / 80 °C

With sodium amide; triethylamine; tert-butyl alcohol; In toluene; benzene;
DOI:10.1055/s-1989-27247

Reference yield:

: 104695-82-1
2,2-Dichloro-3,3,3-trifluoro-1-(4-nitrophenyl)-1-propanol

: 122247-17-0
4-[3-(2,6-Dichloro-phenyl)-5-trifluoromethyl-isoxazol-4-yl]-phenylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Ac₂O, Et₃N, 2.) Fe / 1.) CH₂Cl₂, 40 deg C, 2 h, 2.) aq. EtOH, 80 deg C, 3 h

2: NaNH₂, t-BuOH / benzene; toluene / 1 h / Ambient temperature

3: Et₃N / toluene / 3 h / 80 °C

With acetic anhydride; iron; sodium amide; triethylamine; tert-butyl alcohol; In toluene; benzene;
DOI:10.1055/s-1989-27247