4-[3-(2,6-Dichloro-phenyl)-4-trifluoromethyl-isoxazol-5-yl]-phenylamine

Base Information

• Chemical Name: 4-[3-(2,6-Dichloro-phenyl)-4-trifluoromethyl-isoxazol-5-yl]-phenylamine
• CAS No.: 122247-10-3
• Molecular Formula: C₁₆H₉Cl₂F₃N₂O
• Molecular Weight: 373.161
• Mol file: 122247-10-3.mol

Synonyms:4-[3-(2,6-Dichloro-phenyl)-4-trifluoromethyl-isoxazol-5-yl]-phenylamine

Chemical Property of 4-[3-(2,6-Dichloro-phenyl)-4-trifluoromethyl-isoxazol-5-yl]-phenylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[3-(2,6-Dichloro-phenyl)-4-trifluoromethyl-isoxazol-5-yl]-phenylamine

There total 3 articles about 4-[3-(2,6-Dichloro-phenyl)-4-trifluoromethyl-isoxazol-5-yl]-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

2,6-dichlorobenzohydroximoyl chloride (6579-27-7) + 4-Trifluoroprop-1-ynyl-phenylamine (122247-03-4) → 4-[3-(2,6-Dichloro-phenyl)-5-trifluoromethyl-isoxazol-4-yl]-phenylamine (122247-17-0) + 4-[3-(2,6-Dichloro-phenyl)-4-trifluoromethyl-isoxazol-5-yl]-phenylamine (122247-10-3)

Guidance literature:

With triethylamine; In toluene; at 80 ℃; for 3h; Yields of byproduct given;

DOI:10.1055/s-1989-27247

Reference yield:

1-(4-Aminophenyl)-2-chloro-3,3,3-trifluoropropene (94812-54-1) → 4-[3-(2,6-Dichloro-phenyl)-4-trifluoromethyl-isoxazol-5-yl]-phenylamine (122247-10-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaNH₂, t-BuOH / benzene; toluene / 1 h / Ambient temperature

2: 45 percent / Et₃N / toluene / 3 h / 80 °C

With sodium amide; triethylamine; tert-butyl alcohol; In toluene; benzene;

DOI:10.1055/s-1989-27247

Reference yield:

2,2-Dichloro-3,3,3-trifluoro-1-(4-nitrophenyl)-1-propanol (104695-82-1) → 4-[3-(2,6-Dichloro-phenyl)-4-trifluoromethyl-isoxazol-5-yl]-phenylamine (122247-10-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) Ac₂O, Et₃N, 2.) Fe / 1.) CH₂Cl₂, 40 deg C, 2 h, 2.) aq. EtOH, 80 deg C, 3 h

2: NaNH₂, t-BuOH / benzene; toluene / 1 h / Ambient temperature

3: 45 percent / Et₃N / toluene / 3 h / 80 °C

With acetic anhydride; iron; sodium amide; triethylamine; tert-butyl alcohol; In toluene; benzene;

DOI:10.1055/s-1989-27247

upstream raw materials:

2,6-dichlorobenzohydroximoyl chloride

4-Trifluoroprop-1-ynyl-phenylamine

1-(4-Aminophenyl)-2-chloro-3,3,3-trifluoropropene

2,2-Dichloro-3,3,3-trifluoro-1-(4-nitrophenyl)-1-propanol