2-(4-(6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-nitropyrimidin-4-yloxy)phenyl)propane-1,3-diol

Base Information

• Chemical Name: 2-(4-(6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-nitropyrimidin-4-yloxy)phenyl)propane-1,3-diol
• CAS No.: 1258604-34-0
• Molecular Formula: C₂₃H₂₈N₆O₆
• Molecular Weight: 484.512
• Mol file: 1258604-34-0.mol

Synonyms:2-(4-(6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-nitropyrimidin-4-yloxy)phenyl)propane-1,3-diol

Chemical Property of 2-(4-(6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-nitropyrimidin-4-yloxy)phenyl)propane-1,3-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-nitropyrimidin-4-yloxy)phenyl)propane-1,3-diol

There total 6 articles about 2-(4-(6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-nitropyrimidin-4-yloxy)phenyl)propane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(1-(6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole (1258604-33-9) → 2-(4-(6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-nitropyrimidin-4-yloxy)phenyl)propane-1,3-diol (1258604-34-0)

Guidance literature:

With hydrogenchloride; water; In acetone; at 27 ℃; for 4h;

Reference yield:

diethyl 2-(4'-benzyloxyphenyl)malonate (24220-48-2) → 2-(4-(6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-nitropyrimidin-4-yloxy)phenyl)propane-1,3-diol (1258604-34-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / ethanol / 4 h / 0 - 30 °C

1.2: Cooling with ice

2.1: toluene-4-sulfonic acid / toluene / 18 h / 30 °C

3.1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Reflux

4.1: potassium carbonate / ISOPROPYLAMIDE / 2 h / -20 - -10 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 27 °C / Cooling with ice

6.1: hydrogenchloride; water / acetone / 4 h / 27 °C

With hydrogenchloride; sodium tetrahydroborate; water; ammonium formate; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; toluene-4-sulfonic acid; In methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; acetone; toluene;

Reference yield:

5-(4-(benzyloxy)phenyl)-2,2-dimethyl-1,3-dioxane (1258604-30-6) → 2-(4-(6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-nitropyrimidin-4-yloxy)phenyl)propane-1,3-diol (1258604-34-0)

Guidance literature:

Multi-step reaction with 4 steps

1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Reflux

2: potassium carbonate / ISOPROPYLAMIDE / 2 h / -20 - -10 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 27 °C / Cooling with ice

4: hydrogenchloride; water / acetone / 4 h / 27 °C

With hydrogenchloride; water; ammonium formate; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; dichloromethane; ISOPROPYLAMIDE; acetone;

upstream raw materials:

5-(1-(6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole

2-<4-(phenylmethoxy)phenyl>acetic acid ethyl ester

diethyl 2-(4'-benzyloxyphenyl)malonate

5-(4-(benzyloxy)phenyl)-2,2-dimethyl-1,3-dioxane