4-(N-benzyl-N-methylamino)-1-[2-fluoro-3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl]piperidine

Base Information

Chemical Name:4-(N-benzyl-N-methylamino)-1-[2-fluoro-3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl]piperidine
CAS No.:191212-74-5
Molecular Formula:C₂₆H₃₁FN₆
Molecular Weight:446.571
Hs Code.:

Synonyms:4-(N-benzyl-N-methylamino)-1-[2-fluoro-3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl]piperidine

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Chemical Property of 4-(N-benzyl-N-methylamino)-1-[2-fluoro-3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl]piperidine

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Technology Process of 4-(N-benzyl-N-methylamino)-1-[2-fluoro-3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl]piperidine

There total 6 articles about 4-(N-benzyl-N-methylamino)-1-[2-fluoro-3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-63-0
methanesulfonyl chloride

: 76167-62-9
4-(N-benzyl-N-methylamino)-piperidine

: 191212-74-5
4-(N-benzyl-N-methylamino)-1-[2-fluoro-3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl]piperidine

Guidance literature:: With potassium carbonate; triethylamine; In tetrahydrofuran; water; isopropyl alcohol;

Reference yield:

: 10353-53-4
1,2-epoxy-5-hexene

: 191212-74-5
4-(N-benzyl-N-methylamino)-1-[2-fluoro-3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl]piperidine

Guidance literature:: Multi-step reaction with 6 steps

1: Py*HF / CH₂Cl₂ / 0.33 h / -78 - 20 °C

2: 31 percent / imidazole / dimethylformamide / 22 h

3: 1.) O₃, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂, RT, 15 h

4: 8 percent / 2M aq. HCl / dioxane / 66 h / Heating

5: Et₃N / tetrahydrofuran / 2.2 h / Ambient temperature

6: K₂CO₃ / propan-2-ol / 65 h / Heating

With 1H-imidazole; hydrogenchloride; potassium carbonate; pyridine hydrogenfluoride; ozone; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm981133m

Reference yield:

: 191212-83-6
tert-butyl(2-fluoro-hex-5-enyloxy)dimethylsilane

: 191212-74-5
4-(N-benzyl-N-methylamino)-1-[2-fluoro-3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl]piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) O₃, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂, RT, 15 h

2: 8 percent / 2M aq. HCl / dioxane / 66 h / Heating

3: Et₃N / tetrahydrofuran / 2.2 h / Ambient temperature

4: K₂CO₃ / propan-2-ol / 65 h / Heating

With hydrogenchloride; potassium carbonate; ozone; triethylamine; In tetrahydrofuran; 1,4-dioxane; isopropyl alcohol;
DOI:10.1021/jm981133m