tert-butyl (2R)-6-methyl-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

Base Information

Chemical Name:tert-butyl (2R)-6-methyl-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate
CAS No.:1402851-08-4
Molecular Formula:C₁₇H₂₃NO₂
Molecular Weight:273.375
Hs Code.:

Synonyms:tert-butyl (2R)-6-methyl-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

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Chemical Property of tert-butyl (2R)-6-methyl-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

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Technology Process of tert-butyl (2R)-6-methyl-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

There total 10 articles about tert-butyl (2R)-6-methyl-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1402850-81-0
tert-butyl (2S,3R)-6-methyl-3-nitro-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

: 1402851-08-4
tert-butyl (2R)-6-methyl-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 110 ℃; for 3h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/ol302459c

Reference yield:

: 1402850-61-6
5-nitropent-1-yne

: 1402851-08-4
tert-butyl (2R)-6-methyl-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: C₁₇H₂₁F₆N₃O / toluene / 24 h / -15 °C / Inert atmosphere; Sealed tube

1.2: 0.5 h / 20 °C / Inert atmosphere

1.3: 6 h / 60 °C / Inert atmosphere

2.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 3 h / 110 °C / Inert atmosphere; Microwave irradiation

With 2,2'-azobis(isobutyronitrile); C₁₇H₂₁F₆N₃O; tri-n-butyl-tin hydride; In toluene;
DOI:10.1021/ol302459c

Reference yield:

: 100-52-7
benzaldehyde

: 1402851-08-4
tert-butyl (2R)-6-methyl-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: formic acid / water / Inert atmosphere

2.1: potassium carbonate / tetrahydrofuran / Inert atmosphere

3.1: C₁₇H₂₁F₆N₃O / toluene / 24 h / -15 °C / Inert atmosphere; Sealed tube

3.2: 0.5 h / 20 °C / Inert atmosphere

3.3: 6 h / 60 °C / Inert atmosphere

4.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 3 h / 110 °C / Inert atmosphere; Microwave irradiation

With formic acid; 2,2'-azobis(isobutyronitrile); C₁₇H₂₁F₆N₃O; tri-n-butyl-tin hydride; potassium carbonate; In tetrahydrofuran; water; toluene;
DOI:10.1021/ol302459c