tert-butyl 4-(4-(3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butanamido)-2-(trifiuoromethyl)benzyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butanamido)-2-(trifiuoromethyl)benzyl)piperazine-1-carboxylate
CAS No.:1613169-18-8
Molecular Formula:C₃₃H₄₅BF₃N₃O₅
Molecular Weight:631.544
Hs Code.:

Synonyms:tert-butyl 4-(4-(3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butanamido)-2-(trifiuoromethyl)benzyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-(3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butanamido)-2-(trifiuoromethyl)benzyl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(4-(3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butanamido)-2-(trifiuoromethyl)benzyl)piperazine-1-carboxylate

There total 5 articles about tert-butyl 4-(4-(3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butanamido)-2-(trifiuoromethyl)benzyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 859027-30-8
4-(4-amino-2-trifluoromethyl-benzyl)-piperazine-1-carboxylic acid tert-butyl ester

: 1613169-22-4
3-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]butanoic acid

: 1613169-18-8
tert-butyl 4-(4-(3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butanamido)-2-(trifiuoromethyl)benzyl)piperazine-1-carboxylate

Guidance literature:: With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; for 15h;

Reference yield:

: 73183-34-3
bis(pinacol)diborane

: 1613169-18-8
tert-butyl 4-(4-(3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butanamido)-2-(trifiuoromethyl)benzyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 5 h / 110 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 6 h / 3102.97 Torr

3: lithium hydroxide monohydrate; hydrogen / tetrahydrofuran / 15 h / 20 °C

4: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 15 h

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen; potassium acetate; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol;

Reference yield:

: 1613169-23-5
(E)-ethyl 3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)but-2-enoate

: 1613169-18-8
tert-butyl 4-(4-(3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butanamido)-2-(trifiuoromethyl)benzyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 6 h / 3102.97 Torr

2: lithium hydroxide monohydrate; hydrogen / tetrahydrofuran / 15 h / 20 °C

3: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 15 h

With lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; methanol;