C₂₂H₁₈ClF₃N₂O₄

Base Information

Chemical Name:C₂₂H₁₈ClF₃N₂O₄
CAS No.:1334392-78-7
Molecular Formula:C₂₂H₁₈ClF₃N₂O₄
Molecular Weight:466.844
Hs Code.:

C<sub>22</sub>H<sub>18</sub>ClF<sub>3</sub>N<sub>2</sub>O<sub>4</sub>

Synonyms:C₂₂H₁₈ClF₃N₂O₄

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₂H₁₈ClF₃N₂O₄

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Technology Process of C₂₂H₁₈ClF₃N₂O₄

There total 14 articles about C₂₂H₁₈ClF₃N₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1334392-75-4
C₂₀H₁₃ClF₃NO₅

: 124-40-3
dimethyl amine

: 1334392-78-7
C₂₂H₁₈ClF₃N₂O₄

Guidance literature:: With O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; triethylamine; In DCE; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2011.07.044

Reference yield:

: 958457-41-5
(4-(4-(trifluoromethoxy)phenoxy)phenyl)boronic acid

: 1334392-78-7
C₂₂H₁₈ClF₃N₂O₄

Guidance literature:: Multi-step reaction with 6 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / ethanol; water; toluene / 80 °C

2: ammonia / ethanol; water / 140 °C

3: trichloroisocyanuric acid / methanol; dichloromethane / 0 - 20 °C

4: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 0 - 20 °C

5: sodium chlorite; aminosulfonic acid / water; acetone / 20 °C

6: O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; triethylamine / DCE / 0 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium chlorite; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; trichloroisocyanuric acid; aminosulfonic acid; ammonia; sulfur trioxide pyridine complex; sodium carbonate; dimethyl sulfoxide; triethylamine; In methanol; DCE; ethanol; dichloromethane; water; acetone; toluene;
DOI:10.1016/j.bmcl.2011.07.044

Reference yield:

: 873203-36-2
1-bromo-4-[4-(trifluoromethoxy)phenoxy]benzene

: 1334392-78-7
C₂₂H₁₈ClF₃N₂O₄

Guidance literature:: Multi-step reaction with 8 steps

1: n-butyllithium / tetrahydrofuran / -78 °C

2: hydrogenchloride / water / 20 °C

3: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / ethanol; water; toluene / 80 °C

4: ammonia / ethanol; water / 140 °C

5: trichloroisocyanuric acid / methanol; dichloromethane / 0 - 20 °C

6: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 0 - 20 °C

7: sodium chlorite; aminosulfonic acid / water; acetone / 20 °C

8: O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; triethylamine / DCE / 0 - 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; sodium chlorite; n-butyllithium; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; trichloroisocyanuric acid; aminosulfonic acid; ammonia; sulfur trioxide pyridine complex; sodium carbonate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; DCE; ethanol; dichloromethane; water; acetone; toluene;
DOI:10.1016/j.bmcl.2011.07.044