2-Benzyl-2-((S)-3-benzyloxycarbonylamino-5-methyl-2-oxo-hexyl)-malonic acid

Base Information

Chemical Name:2-Benzyl-2-((S)-3-benzyloxycarbonylamino-5-methyl-2-oxo-hexyl)-malonic acid
CAS No.:128117-73-7
Molecular Formula:C₂₅H₂₉NO₇
Molecular Weight:455.508
Hs Code.:

Synonyms:2-Benzyl-2-((S)-3-benzyloxycarbonylamino-5-methyl-2-oxo-hexyl)-malonic acid

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Chemical Property of 2-Benzyl-2-((S)-3-benzyloxycarbonylamino-5-methyl-2-oxo-hexyl)-malonic acid

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Technology Process of 2-Benzyl-2-((S)-3-benzyloxycarbonylamino-5-methyl-2-oxo-hexyl)-malonic acid

There total 9 articles about 2-Benzyl-2-((S)-3-benzyloxycarbonylamino-5-methyl-2-oxo-hexyl)-malonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2018-66-8
Z-Leu-OH

: 128117-73-7
2-Benzyl-2-((S)-3-benzyloxycarbonylamino-5-methyl-2-oxo-hexyl)-malonic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1) isobutyl chloroformate, TEA / 1) Et₂O, -15 deg C, 15 min, 2) Et₂O, -15 deg C, 2 h

2: 96 percent / HBr / diethyl ether / 5 °C

3: 1) NaH, HMPA, 2) HMPA / 1) DMF, 25 deg C, 40 min, 2) DMF, 25 deg C, 2 h

4: 1 N NaOH / ethanol

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; TEA; hydrogen bromide; sodium hydride; isobutyl chloroformate; In diethyl ether; ethanol;
DOI:10.1021/jm00126a039

Reference yield:

: 102123-81-9
(3-diazo-1-(S)-(2-methylpropyl)-2-oxopropyl)carbamic acid benzyl ester

: 128117-73-7
2-Benzyl-2-((S)-3-benzyloxycarbonylamino-5-methyl-2-oxo-hexyl)-malonic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / HBr / diethyl ether / 5 °C

2: 1) NaH, HMPA, 2) HMPA / 1) DMF, 25 deg C, 40 min, 2) DMF, 25 deg C, 2 h

3: 1 N NaOH / ethanol

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; hydrogen bromide; sodium hydride; In diethyl ether; ethanol;
DOI:10.1021/jm00126a039

Reference yield:

: 118252-77-0
(3S)-3-<(benzyloxycarbonyl)amino>-1-bromo-5-methyl-2-oxohexane

: 128117-73-7
2-Benzyl-2-((S)-3-benzyloxycarbonylamino-5-methyl-2-oxo-hexyl)-malonic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1) NaH, HMPA, 2) HMPA / 1) DMF, 25 deg C, 40 min, 2) DMF, 25 deg C, 2 h

2: 1 N NaOH / ethanol

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; sodium hydride; In ethanol;
DOI:10.1021/jm00126a039