118252-77-0

Upstream product

• 102123-80-8 C₁₉H₂₇NO₆ 
• 2018-66-8 Z-Leu-OH 
• 102123-81-9 (3-diazo-1-(S)-(2-methylpropyl)-2-oxopropyl)carbamic acid benzyl ester 
• 148854-04-0 (C₈H₇O₂)(NHCHCOO)(CH₂C₃H₇)(CO₂C₂H₅) 

Downstream Products

• 269085-47-4 benzyl (S)-1-(1H-imidazol-4-yl)-3-methylbutylcarbamate 
• 1237502-06-5 C₂₂H₂₉N₅O₆ 
• 1237501-94-8 C₁₈H₂₂N₄O₅ 
• 1237501-76-6 Z-Leu-CH₂N₃ 
• 118388-59-3 (S)-5-Benzyloxycarbonylamino-2-isobutyl-7-methyl-4-oxo-octanoic acid 
• 93092-75-2 (S)-5-Benzyloxycarbonylamino-7-methyl-4-oxo-octanoic acid 
• 128117-73-7 2-Benzyl-2-((S)-3-benzyloxycarbonylamino-5-methyl-2-oxo-hexyl)-malonic acid 
• 118404-36-7 (2RS,5S)-2-benzyl-5-<(benzyloxycarbonyl)amino>-7-methyl-4-oxooctanoic acid 
• 852248-40-9 (S)-3-methyl-1-(2-phenyl-1H-imidazol-4-yl)butan-1-amine 

Relevant academic research and scientific papers

Facile synthesis of optically active imidazole derivatives

Five optically active imidazole derivatives have been synthesized via a facile 4-step reaction sequence starting from commercially available and inexpensive N-Cbz amino acids. While microwave assisted condensation was unsuccessful, the condensation of the

Chiral imidazole derivatives synthesis from enantiopure N-protected α-amino acids

A route to the preparation of enantiopure ligands based on a 2-phenylimidazol ring is described. The stereogenic centre is placed into the chain bonded to the fourth carbon of the imidazole ring. The synthesis starts from inexpensive and readily available

Stereocontrolled synthesis of erythro N-protected α-amino epoxides and peptidyl epoxides

N-protected α-amino epoxides of erythro configuration, derived from α-amino acids, were synthesized in a stereoselective manner. The erythro (2S,3S), configuration was achieved by the synthetic sequence: amino acid -> haloketone -> halohydrin -> epoxide. A mechanistic explanation for the observed stereoselectivity is presented. This stereoselective synthetic approach was applied to the synthesis of a variety of short peptidyl epoxides, bearing a predefined absolute configuration of the chiral epoxide moiety.

Renin inhibitors containing isosteric replacements of the amide bond connecting the P3 and P2 sites

Renin inhibitors having 13 different isosteres connecting the P3 and P2 positions have been prepared. Synthetic routes and in vitro activity exhibited by these compounds are discussed. The two most potent compounds, 47 and 48, contai

Inhibition of aminopeptidases by peptides containing ketomethylene and hydroxyethylene amide bond replacements

Inhibitors of aminopeptidase enzymes have been prepared by the synthesis of peptide substrate analogues in which the scissile amide bond has been replaced with the hydrolytically stable ketomethylene (-COCH2-) and hydroxyethylene [-CH(OH)CHsub