(E)-8-acetyl-1-methyl-5-(3-oxo-3-p-tolylprop-1-enyl)chromeno[8,7-h]chromene-3,9-dione

Base Information

Chemical Name:(E)-8-acetyl-1-methyl-5-(3-oxo-3-p-tolylprop-1-enyl)chromeno[8,7-h]chromene-3,9-dione
CAS No.:1323444-51-4
Molecular Formula:C₂₉H₂₀O₆
Molecular Weight:464.474
Hs Code.:

Synonyms:(E)-8-acetyl-1-methyl-5-(3-oxo-3-p-tolylprop-1-enyl)chromeno[8,7-h]chromene-3,9-dione

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Chemical Property of (E)-8-acetyl-1-methyl-5-(3-oxo-3-p-tolylprop-1-enyl)chromeno[8,7-h]chromene-3,9-dione

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Technology Process of (E)-8-acetyl-1-methyl-5-(3-oxo-3-p-tolylprop-1-enyl)chromeno[8,7-h]chromene-3,9-dione

There total 4 articles about (E)-8-acetyl-1-methyl-5-(3-oxo-3-p-tolylprop-1-enyl)chromeno[8,7-h]chromene-3,9-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1259925-35-3
(E)-7-hydroxy-4-methyl-2-oxo-10-(3-oxo-3-p-tolylprop-1-enyl)-2H-benzo[h]chromene-8-carbaldehyde

: 141-97-9
ethyl acetoacetate

: 1323444-51-4
(E)-8-acetyl-1-methyl-5-(3-oxo-3-p-tolylprop-1-enyl)chromeno[8,7-h]chromene-3,9-dione

Guidance literature:: With piperidine; In ethanol; for 0.5h; Reflux;
DOI:10.1016/j.bmcl.2011.06.002

Reference yield:

: 933774-89-1
7-hydroxy-4-methyl-2-oxo-2H-benzo[h]chromene-8,10-dicarbaldehyde

: 1323444-51-4
(E)-8-acetyl-1-methyl-5-(3-oxo-3-p-tolylprop-1-enyl)chromeno[8,7-h]chromene-3,9-dione

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; water / 5 h / Reflux

2: piperidine / ethanol / 0.5 h / Reflux

With piperidine; hydrogenchloride; In 1,4-dioxane; ethanol; water; 2: Knoevenagel condensation;
DOI:10.1016/j.bmcl.2011.06.002

Reference yield:

: 83-56-7
1,5-dihydroxynaphthalene

: 1323444-51-4
(E)-8-acetyl-1-methyl-5-(3-oxo-3-p-tolylprop-1-enyl)chromeno[8,7-h]chromene-3,9-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / 8 h / 75 °C

2.1: trifluoroacetic acid / 4 h / 120 °C

2.2: 1 h / 100 °C

3.1: hydrogenchloride / 1,4-dioxane; water / 5 h / Reflux

4.1: piperidine / ethanol / 0.5 h / Reflux

With piperidine; hydrogenchloride; toluene-4-sulfonic acid; trifluoroacetic acid; In 1,4-dioxane; ethanol; water; 1.1: Pechmann condensation / 2.1: Duff reaction / 2.2: Duff reaction / 4.1: Knoevenagel condensation;
DOI:10.1016/j.bmcl.2011.06.002