(E)-7-hydroxy-4-methyl-2-oxo-10-(3-oxo-3-p-tolylprop-1-enyl)-2H-benzo[h]chromene-8-carbaldehyde

Base Information

Chemical Name:(E)-7-hydroxy-4-methyl-2-oxo-10-(3-oxo-3-p-tolylprop-1-enyl)-2H-benzo[h]chromene-8-carbaldehyde
CAS No.:1259925-35-3
Molecular Formula:C₂₅H₁₈O₅
Molecular Weight:398.415
Hs Code.:

Synonyms:(E)-7-hydroxy-4-methyl-2-oxo-10-(3-oxo-3-p-tolylprop-1-enyl)-2H-benzo[h]chromene-8-carbaldehyde

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Chemical Property of (E)-7-hydroxy-4-methyl-2-oxo-10-(3-oxo-3-p-tolylprop-1-enyl)-2H-benzo[h]chromene-8-carbaldehyde

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Technology Process of (E)-7-hydroxy-4-methyl-2-oxo-10-(3-oxo-3-p-tolylprop-1-enyl)-2H-benzo[h]chromene-8-carbaldehyde

There total 3 articles about (E)-7-hydroxy-4-methyl-2-oxo-10-(3-oxo-3-p-tolylprop-1-enyl)-2H-benzo[h]chromene-8-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 933774-89-1
7-hydroxy-4-methyl-2-oxo-2H-benzo[h]chromene-8,10-dicarbaldehyde

: 122-00-9
para-methylacetophenone

: 1259925-35-3
(E)-7-hydroxy-4-methyl-2-oxo-10-(3-oxo-3-p-tolylprop-1-enyl)-2H-benzo[h]chromene-8-carbaldehyde

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 5h; regioselective reaction; Reflux;
DOI:10.1016/j.bmcl.2010.09.040

Reference yield:

: 21353-16-2
7-hydroxy-4-methyl-benzo[h]chromen-2-one

: 1259925-35-3
(E)-7-hydroxy-4-methyl-2-oxo-10-(3-oxo-3-p-tolylprop-1-enyl)-2H-benzo[h]chromene-8-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / 4 h / 120 °C

1.2: 1 h / 100 °C

2.1: hydrogenchloride / 1,4-dioxane; water / 5 h / Reflux

With hydrogenchloride; trifluoroacetic acid; In 1,4-dioxane; water; 1.1: Duff reaction / 1.2: Duff reaction;
DOI:10.1016/j.bmcl.2011.06.002

Reference yield:

: 83-56-7
1,5-dihydroxynaphthalene

: 1259925-35-3
(E)-7-hydroxy-4-methyl-2-oxo-10-(3-oxo-3-p-tolylprop-1-enyl)-2H-benzo[h]chromene-8-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / 8 h / 75 °C

2.1: trifluoroacetic acid / 4 h / 120 °C

2.2: 1 h / 100 °C

3.1: hydrogenchloride / 1,4-dioxane; water / 5 h / Reflux

With hydrogenchloride; toluene-4-sulfonic acid; trifluoroacetic acid; In 1,4-dioxane; water; 1.1: Pechmann condensation / 2.1: Duff reaction / 2.2: Duff reaction;
DOI:10.1016/j.bmcl.2011.06.002