1-(4-Bromo-2,6-dimethyl-benzoylamino)-cyclopropanecarboxylic acid ethyl ester

Base Information

• Chemical Name: 1-(4-Bromo-2,6-dimethyl-benzoylamino)-cyclopropanecarboxylic acid ethyl ester
• CAS No.: 1233333-58-8
• Molecular Formula: C₁₅H₁₈BrNO₃
• Molecular Weight: 340.217
• Mol file: 1233333-58-8.mol

Synonyms:1-(4-Bromo-2,6-dimethyl-benzoylamino)-cyclopropanecarboxylic acid ethyl ester

Chemical Property of 1-(4-Bromo-2,6-dimethyl-benzoylamino)-cyclopropanecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 1-(4-Bromo-2,6-dimethyl-benzoylamino)-cyclopropanecarboxylic acid ethyl ester

There total 1 articles about 1-(4-Bromo-2,6-dimethyl-benzoylamino)-cyclopropanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Brom-2,6-dimethylbenzoylchlorid (74346-20-6) + ethyl 1-aminocyclopropanecarboxylate hydrochloride (42303-42-4) → 1-(4-Bromo-2,6-dimethyl-benzoylamino)-cyclopropanecarboxylic acid ethyl ester (1233333-58-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

1-(4-Bromo-2,6-dimethyl-benzoylamino)-cyclopropanecarboxylic acid ethyl ester (1233333-58-8) + bis(pinacol)diborane (73183-34-3) → 1-[2,6-Dimethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoylamino]-cyclopropanecarboxylic acid ethyl ester (1233333-75-9)

Guidance literature:

With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 80 ℃; Inert atmosphere;

Reference yield:

1-(4-Bromo-2,6-dimethyl-benzoylamino)-cyclopropanecarboxylic acid ethyl ester (1233333-58-8) + methyl iodide (74-88-4) → 1-[(4-bromo-2,6-dimethyl-benzoyl)-methyl-amino]-cyclopropanecarboxylic acid ethyl ester (1233333-59-9)

Guidance literature:

1-(4-Bromo-2,6-dimethyl-benzoylamino)-cyclopropanecarboxylic acid ethyl ester; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 18h;

upstream raw materials:

4-Brom-2,6-dimethylbenzoylchlorid

ethyl 1-aminocyclopropanecarboxylate hydrochloride

Downstream raw materials:

1-[(4-bromo-2,6-dimethyl-benzoyl)-methyl-amino]-cyclopropanecarboxylic acid ethyl ester

1-[2,6-Dimethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoylamino]-cyclopropanecarboxylic acid ethyl ester