Technology Process of 2,6-dichloro-4'-fluorobiphenyl-4-carboxaldehyde
There total 3 articles about 2,6-dichloro-4'-fluorobiphenyl-4-carboxaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2,6-dichloro-4'-fluorobiphenyl-4-yl)methanol;
With
oxalyl dichloride; dimethyl sulfoxide;
In
dichloromethane;
at -78 ℃;
for 1h;
Inert atmosphere;
Cooling with acetone-dry ice;
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at -78 - 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 0.5 h / 115 °C / Inert atmosphere; microwave irradiation; sealed vial
2.1: dimethylsulfide borane complex / tetrahydrofuran / 20 h / 20 °C
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere; Cooling with acetone-dry ice
3.2: 1 h / -78 - 20 °C
With
oxalyl dichloride; dimethylsulfide borane complex; potassium carbonate; dimethyl sulfoxide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,4-dioxane; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: dimethylsulfide borane complex / tetrahydrofuran / 20 h / 20 °C
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere; Cooling with acetone-dry ice
2.2: 1 h / -78 - 20 °C
With
oxalyl dichloride; dimethylsulfide borane complex; dimethyl sulfoxide;
In
tetrahydrofuran; dichloromethane;
