4-{8-[(2,6-dichloro-4'-fluorobiphenyl-4-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate

Base Information

Chemical Name:4-{8-[(2,6-dichloro-4'-fluorobiphenyl-4-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate
CAS No.:1350758-55-2
Molecular Formula:C₂HF₃O₂*C₂₇H₂₃Cl₂FN₂O₃
Molecular Weight:627.42
Hs Code.:

Synonyms:4-{8-[(2,6-dichloro-4'-fluorobiphenyl-4-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate

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Chemical Property of 4-{8-[(2,6-dichloro-4'-fluorobiphenyl-4-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate

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Technology Process of 4-{8-[(2,6-dichloro-4'-fluorobiphenyl-4-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate

There total 4 articles about 4-{8-[(2,6-dichloro-4'-fluorobiphenyl-4-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350760-15-4
2,6-dichloro-4'-fluorobiphenyl-4-carboxaldehyde

: 1350759-92-0
3-(4-carboxyphenyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene hydrochloride

: 1350758-55-2
4-{8-[(2,6-dichloro-4'-fluorobiphenyl-4-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate

Guidance literature:: With acetic acid; In N,N-dimethyl-formamide; at 20 ℃; for 18h; scintillation vial;

Reference yield:

: 117757-68-3
3,5-dichloro-4-iodobenzoic acid

: 1350758-55-2
4-{8-[(2,6-dichloro-4'-fluorobiphenyl-4-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 115 °C / Inert atmosphere; microwave irradiation; sealed vial

2.1: dimethylsulfide borane complex / tetrahydrofuran / 20 h / 20 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere; Cooling with acetone-dry ice

3.2: 1 h / -78 - 20 °C

4.1: acetic acid / N,N-dimethyl-formamide / 18 h / 20 °C / scintillation vial

With oxalyl dichloride; dimethylsulfide borane complex; potassium carbonate; acetic acid; dimethyl sulfoxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1350760-11-0
2,6-dichloro-4'-fluorobiphenyl-4-carboxylic acid

: 1350758-55-2
4-{8-[(2,6-dichloro-4'-fluorobiphenyl-4-yl)methyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 20 h / 20 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere; Cooling with acetone-dry ice

2.2: 1 h / -78 - 20 °C

3.1: acetic acid / N,N-dimethyl-formamide / 18 h / 20 °C / scintillation vial

With oxalyl dichloride; dimethylsulfide borane complex; acetic acid; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;