N-acetyl-4-[3-(2-cyclohexylethoxy)benzyl]piperazine-1-carboxamide oxalate

Base Information

Chemical Name:N-acetyl-4-[3-(2-cyclohexylethoxy)benzyl]piperazine-1-carboxamide oxalate
CAS No.:1008764-49-5
Molecular Formula:C₂H₂O₄*C₂₂H₃₃N₃O₃
Molecular Weight:477.558
Hs Code.:

Synonyms:N-acetyl-4-[3-(2-cyclohexylethoxy)benzyl]piperazine-1-carboxamide oxalate

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Chemical Property of N-acetyl-4-[3-(2-cyclohexylethoxy)benzyl]piperazine-1-carboxamide oxalate

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Technology Process of N-acetyl-4-[3-(2-cyclohexylethoxy)benzyl]piperazine-1-carboxamide oxalate

There total 5 articles about N-acetyl-4-[3-(2-cyclohexylethoxy)benzyl]piperazine-1-carboxamide oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1008775-43-6
4-[3-(2-cyclohexylethoxy)benzyl]piperazine-1-carboxamide

: 144-62-7,97993-78-7
oxalic acid

: 75-36-5
acetyl chloride

: 1008764-49-5
N-acetyl-4-[3-(2-cyclohexylethoxy)benzyl]piperazine-1-carboxamide oxalate

Guidance literature:: 4-[3-(2-cyclohexylethoxy)benzyl]piperazine-1-carboxamide; acetyl chloride; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 3h;

With sodium hydroxide; ethanol; water; at 0 ℃; for 0.5h;

oxalic acid; In acetone; for 0.166667h;

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 1008764-49-5
N-acetyl-4-[3-(2-cyclohexylethoxy)benzyl]piperazine-1-carboxamide oxalate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 5 h / 0 - 20 °C

2.1: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 2 h / 0 - 20 °C

3.1: hydrogenchloride / ethyl acetate / 3 h

4.1: hydrogenchloride; methanol; water / 1 h

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 3 h / 20 °C

5.2: 0.5 h / 0 °C

5.3: 0.17 h

With hydrogenchloride; methanol; water; sodium tris(acetoxy)borohydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene;

Reference yield:

: 4442-79-9
cyclohexylethan-1-ol

: 1008764-49-5
N-acetyl-4-[3-(2-cyclohexylethoxy)benzyl]piperazine-1-carboxamide oxalate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 5 h / 0 - 20 °C

2.1: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 2 h / 0 - 20 °C

3.1: hydrogenchloride / ethyl acetate / 3 h

4.1: hydrogenchloride; methanol; water / 1 h

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 3 h / 20 °C

5.2: 0.5 h / 0 °C

5.3: 0.17 h

With hydrogenchloride; methanol; water; sodium tris(acetoxy)borohydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene;