3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)naphthalen-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylic acid

Base Information

Chemical Name:3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)naphthalen-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylic acid
CAS No.:1544657-44-4
Molecular Formula:C₃₀H₄₁NO₃
Molecular Weight:463.66
Hs Code.:

Synonyms:3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)naphthalen-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylic acid

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Chemical Property of 3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)naphthalen-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylic acid

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Technology Process of 3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)naphthalen-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylic acid

There total 5 articles about 3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)naphthalen-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1544662-19-2
methyl 3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)naphthalen-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylate

: 1544657-44-4
3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)naphthalen-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylic acid

Guidance literature:: With water; sodium hydroxide; In methanol; at 65 ℃; for 4h;

Reference yield:

: 1544662-04-5
2-bromo-6-((cis-4-isopropylcyclohexyl)oxy)naphthalene

: 1544657-44-4
3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)naphthalen-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: triethylamine / 2 h / 20 °C

2.2: 16 h / 20 °C

3.1: water; sodium hydroxide / methanol / 4 h / 65 °C

With n-butyllithium; water; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol;

Reference yield:

: 15890-36-5
trans-4-isopropylcyclohexanol

: 1544657-44-4
3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)naphthalen-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

3.1: triethylamine / 2 h / 20 °C

3.2: 16 h / 20 °C

4.1: water; sodium hydroxide / methanol / 4 h / 65 °C

With n-butyllithium; di-isopropyl azodicarboxylate; water; triethylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol;