methyl 3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)naphthalen-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylate

Base Information

Chemical Name:methyl 3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)naphthalen-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylate
CAS No.:1544662-19-2
Molecular Formula:C₃₁H₄₃NO₃
Molecular Weight:477.687
Hs Code.:

Synonyms:methyl 3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)naphthalen-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylate

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Chemical Property of methyl 3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)naphthalen-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylate

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Technology Process of methyl 3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)naphthalen-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylate

There total 4 articles about methyl 3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)naphthalen-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 67-56-1
methanol

: 1544662-06-7
6-((cis-4-isopropylcyclohexyl)oxy)-2-naphthaldehyde

: 1544665-32-8
3-(azetidin-3-yl)cyclohexanecarboxylic acid hydrochloride

: 1544662-19-2
methyl 3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)naphthalen-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylate

Guidance literature:: methanol; 6-((cis-4-isopropylcyclohexyl)oxy)-2-naphthaldehyde; 3-(azetidin-3-yl)cyclohexanecarboxylic acid hydrochloride; With triethylamine; at 20 ℃; for 2h;

With sodium cyanoborohydride; at 20 ℃; for 16h;

Reference yield:

: 1544662-04-5
2-bromo-6-((cis-4-isopropylcyclohexyl)oxy)naphthalene

: 1544662-19-2
methyl 3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)naphthalen-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: triethylamine / 2 h / 20 °C

2.2: 16 h / 20 °C

With n-butyllithium; triethylamine; In tetrahydrofuran;

Reference yield:

: 15890-36-5
trans-4-isopropylcyclohexanol

: 1544662-19-2
methyl 3-(1-((6-((cis-4-isopropylcyclohexyl)oxy)naphthalen-2-yl)methyl)azetidin-3-yl)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

3.1: triethylamine / 2 h / 20 °C

3.2: 16 h / 20 °C

With n-butyllithium; di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In tetrahydrofuran;