Technology Process of 9-methyl-5,8-dideazaisofolic acid
There total 8 articles about 9-methyl-5,8-dideazaisofolic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 75 percent / dimethylformamide / 48 h / Heating
2: 54 percent / H2, glacial AcOH / 10percent Pd/C / dimethylformamide
3: 52 percent / H2 / Raney Ni / acetic acid
4: 81.5 percent / CF3COOH / 1 h / Ambient temperature
5: NaB(CN)H3 / H2O / 20 h
With
hydrogen; sodium cyanoborohydride; acetic acid; trifluoroacetic acid;
palladium on activated charcoal; nickel;
In
water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00368a023
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 4-methylmorpholine / dimethylformamide / 1.) -15 deg C, 45 min, 2.) 20 deg C, 18 h
2: 52 percent / H2 / Raney Ni / acetic acid
3: 81.5 percent / CF3COOH / 1 h / Ambient temperature
4: NaB(CN)H3 / H2O / 20 h
With
4-methyl-morpholine; hydrogen; sodium cyanoborohydride; trifluoroacetic acid;
nickel;
In
water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00368a023
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 52 percent / H2 / Raney Ni / acetic acid
2: 81.5 percent / CF3COOH / 1 h / Ambient temperature
3: NaB(CN)H3 / H2O / 20 h
With
hydrogen; sodium cyanoborohydride; trifluoroacetic acid;
nickel;
In
water; acetic acid;
DOI:10.1021/jm00368a023
