2-(Diphenylphosphinyl)-1-(2-furanyl)ethanone

Base Information

• Chemical Name: 2-(Diphenylphosphinyl)-1-(2-furanyl)ethanone
• CAS No.: 910912-35-5
• Molecular Formula: C₁₈H₁₅O₃P
• Molecular Weight: 310.289
• DSSTox Substance ID: DTXSID701258100
• Nikkaji Number: J3.643.586K
• Mol file: 910912-35-5.mol

Synonyms:2-(Diphenylphosphinyl)-1-(2-furanyl)ethanone;DTXSID701258100;910912-35-5

Chemical Property of 2-(Diphenylphosphinyl)-1-(2-furanyl)ethanone

Chemical Property:

• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 310.07588133
• Heavy Atom Count: 22
• Complexity: 400

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)P(=O)(CC(=O)C2=CC=CO2)C3=CC=CC=C3

Technology Process of 2-(Diphenylphosphinyl)-1-(2-furanyl)ethanone

There total 3 articles about 2-(Diphenylphosphinyl)-1-(2-furanyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-furoic acid methyl ester (611-13-2) + diphenyl(methyl)phosphine oxide (2129-89-7) → 2-(diphenylphosphoryl)-1-(furan-2-yl)ethan-1-one (910912-35-5)

Guidance literature:

diphenyl(methyl)phosphine oxide; With n-butyllithium; In tetrahydrofuran; at 0 ℃; for 0.25h;

2-furoic acid methyl ester; In tetrahydrofuran; at -78 ℃; for 3h; Further stages.;

DOI:10.1039/b606873a

Reference yield: 63.0%

C14H20N2O5 + Diphenylphosphine oxide (4559-70-0) → 2-(diphenylphosphoryl)-1-(furan-2-yl)ethan-1-one (910912-35-5)

Guidance literature:

With triethylamine; copper(ll) bromide; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/j.tetlet.2017.05.005

Reference yield:

1-(2-furyl)-1-ethanone (1192-62-7,80145-44-4) → 2-(diphenylphosphoryl)-1-(furan-2-yl)ethan-1-one (910912-35-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tributylphosphine / dichloromethane / 4 h / 20 °C

2: triethylamine; copper(ll) bromide / dichloromethane / 12 h / 20 °C

With tributylphosphine; triethylamine; copper(ll) bromide; In dichloromethane;

DOI:10.1016/j.tetlet.2017.05.005

upstream raw materials:

2-furoic acid methyl ester

diphenyl(methyl)phosphine oxide

1-(2-furyl)-1-ethanone

Diphenylphosphine oxide

Downstream raw materials:

(E)-2-diphenylphosphinoyl-1-furan-2-yl-5-phenyl-pent-4-en-1-one

(E)-1-furan-2-yl-5-phenyl-pent-4-en-1-one