(E)-2-diphenylphosphinoyl-1-furan-2-yl-5-phenyl-pent-4-en-1-one

Base Information

• Chemical Name: (E)-2-diphenylphosphinoyl-1-furan-2-yl-5-phenyl-pent-4-en-1-one
• CAS No.: 910912-38-8
• Molecular Formula: C₂₇H₂₃O₃P
• Molecular Weight: 426.452
• Mol file: 910912-38-8.mol

Synonyms:(E)-2-diphenylphosphinoyl-1-furan-2-yl-5-phenyl-pent-4-en-1-one

Chemical Property of (E)-2-diphenylphosphinoyl-1-furan-2-yl-5-phenyl-pent-4-en-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-diphenylphosphinoyl-1-furan-2-yl-5-phenyl-pent-4-en-1-one

There total 3 articles about (E)-2-diphenylphosphinoyl-1-furan-2-yl-5-phenyl-pent-4-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-(diphenylphosphoryl)-1-(furan-2-yl)ethan-1-one (910912-35-5) + Cinnamyl bromide (4392-24-9) → (E)-2-diphenylphosphinoyl-1-furan-2-yl-5-phenyl-pent-4-en-1-one (910912-38-8)

Guidance literature:

2-(diphenylphosphoryl)-1-(furan-2-yl)ethan-1-one; With sodium methylate; In tetrahydrofuran; at 20 ℃; for 0.25h;

Cinnamyl bromide; In tetrahydrofuran; at 20 ℃; for 19h; Further stages.;

DOI:10.1039/b606873a

Reference yield:

2-furoic acid methyl ester (611-13-2) → (E)-2-diphenylphosphinoyl-1-furan-2-yl-5-phenyl-pent-4-en-1-one (910912-38-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran / 0.25 h / 0 °C

1.2: 76 percent / tetrahydrofuran / 3 h / -78 °C

2.1: NaOMe / tetrahydrofuran / 0.25 h / 20 °C

2.2: 83 percent / tetrahydrofuran / 19 h / 20 °C

With n-butyllithium; sodium methylate; In tetrahydrofuran;

DOI:10.1039/b606873a

Reference yield:

diphenyl(methyl)phosphine oxide (2129-89-7) → (E)-2-diphenylphosphinoyl-1-furan-2-yl-5-phenyl-pent-4-en-1-one (910912-38-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran / 0.25 h / 0 °C

1.2: 76 percent / tetrahydrofuran / 3 h / -78 °C

2.1: NaOMe / tetrahydrofuran / 0.25 h / 20 °C

2.2: 83 percent / tetrahydrofuran / 19 h / 20 °C

With n-butyllithium; sodium methylate; In tetrahydrofuran;

DOI:10.1039/b606873a

upstream raw materials:

2-(diphenylphosphoryl)-1-(furan-2-yl)ethan-1-one

Cinnamyl bromide

2-furoic acid methyl ester

diphenyl(methyl)phosphine oxide

Downstream raw materials:

(E)-1-furan-2-yl-5-phenyl-pent-4-en-1-one