α,α-Bis(4-fluorophenyl)-1-[3-(4-methylphenoxy)propyl]-4-piperidinemethanol fumarate

Base Information

Chemical Name:α,α-Bis(4-fluorophenyl)-1-[3-(4-methylphenoxy)propyl]-4-piperidinemethanol fumarate
CAS No.:117023-51-5
Molecular Formula:C₄H₄O₄*C₂₈H₃₁F₂NO₂
Molecular Weight:567.63
Hs Code.:

Synonyms:α,α-Bis(4-fluorophenyl)-1-[3-(4-methylphenoxy)propyl]-4-piperidinemethanol fumarate

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Chemical Property of α,α-Bis(4-fluorophenyl)-1-[3-(4-methylphenoxy)propyl]-4-piperidinemethanol fumarate

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Technology Process of α,α-Bis(4-fluorophenyl)-1-[3-(4-methylphenoxy)propyl]-4-piperidinemethanol fumarate

There total 6 articles about α,α-Bis(4-fluorophenyl)-1-[3-(4-methylphenoxy)propyl]-4-piperidinemethanol fumarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 79096-53-0
(3-chloro-propyl)-p-tolyl ether

: 60284-98-2
1,1-bis(4-fluorophenyl)-1-(4-piperidinyl)methanol

: 110-17-8,26099-09-2
(2E)-but-2-enedioic acid

: 117023-51-5
α,α-Bis(4-fluorophenyl)-1-[3-(4-methylphenoxy)propyl]-4-piperidinemethanol fumarate

Guidance literature:: With sodium carbonate; potassium iodide; 1) n-butanol, reflux;
DOI:10.1021/jm00121a022

Reference yield:

: florisil

: 79096-53-0
(3-chloro-propyl)-p-tolyl ether

: 60284-98-2
1,1-bis(4-fluorophenyl)-1-(4-piperidinyl)methanol

: 117023-51-5
α,α-Bis(4-fluorophenyl)-1-[3-(4-methylphenoxy)propyl]-4-piperidinemethanol fumarate

Guidance literature:: With potassium iodide; sodium carbonate; In butan-1-ol; benzene;

Reference yield:

: 24228-40-8
N-benzyl isonipecotic acid ethyl ester

: 117023-51-5
α,α-Bis(4-fluorophenyl)-1-[3-(4-methylphenoxy)propyl]-4-piperidinemethanol fumarate

Guidance literature:: Multi-step reaction with 3 steps

1: 1) Mg / 1) THF, reflux, 15 min.; 2) THF, room temperature, overnight

2: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

3: 56 percent / 1) Na₂CO₃, KI / 1) n-butanol, reflux

With hydrogen; sodium carbonate; magnesium; potassium iodide; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00121a022