methyl 4-(4-hydroxy-5-oxo-3-phenyl-2,5-dihydro-2-furyl)butyrate

Base Information

• Chemical Name: methyl 4-(4-hydroxy-5-oxo-3-phenyl-2,5-dihydro-2-furyl)butyrate
• CAS No.: 117085-38-8
• Molecular Formula: C₁₅H₁₆O₅
• Molecular Weight: 276.289
• Mol file: 117085-38-8.mol

Synonyms:methyl 4-(4-hydroxy-5-oxo-3-phenyl-2,5-dihydro-2-furyl)butyrate

Chemical Property of methyl 4-(4-hydroxy-5-oxo-3-phenyl-2,5-dihydro-2-furyl)butyrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(4-hydroxy-5-oxo-3-phenyl-2,5-dihydro-2-furyl)butyrate

There total 2 articles about methyl 4-(4-hydroxy-5-oxo-3-phenyl-2,5-dihydro-2-furyl)butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

methyl 4-formylbutanoate (6026-86-4) + methyl phenylpyruvate (6362-58-9) → methyl 4-(4-hydroxy-5-oxo-3-phenyl-2,5-dihydro-2-furyl)butyrate (117085-38-8)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.35.2594

Reference yield:

2-oxo-3-(phenyl)propionic acid (156-06-9) → methyl 4-(4-hydroxy-5-oxo-3-phenyl-2,5-dihydro-2-furyl)butyrate (117085-38-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / DBU / dimethylformamide / 2.5 h / 0 °C

2: 45 percent / DBU / dimethylformamide / 2.5 h

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.36.1404

Reference yield: 88.0%

methyl 4-(4-hydroxy-5-oxo-3-phenyl-2,5-dihydro-2-furyl)butyrate (117085-38-8) → 4-(4-hydroxy-5-oxo-3-phenyl-2,5-dihydro-2-furyl)butyric acid (117085-40-2)

Guidance literature:

With hydrogenchloride; acetic acid; at 100 ℃; for 1h;

DOI:10.1248/cpb.35.2594

upstream raw materials:

methyl 4-formylbutanoate

methyl phenylpyruvate

2-oxo-3-(phenyl)propionic acid

Downstream raw materials:

4-(4-hydroxy-5-oxo-3-phenyl-2,5-dihydro-2-furyl)butyric acid