diethyl N-[4-[2-(2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-ylmethyl) methylamino]benzoyl]-L-glutamate

Base Information

Chemical Name:diethyl N-[4-[2-(2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-ylmethyl) methylamino]benzoyl]-L-glutamate
CAS No.:1383672-71-6
Molecular Formula:C₂₅H₃₅N₇O₅
Molecular Weight:513.597
Hs Code.:

Synonyms:diethyl N-[4-[2-(2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-ylmethyl) methylamino]benzoyl]-L-glutamate

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Chemical Property of diethyl N-[4-[2-(2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-ylmethyl) methylamino]benzoyl]-L-glutamate

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Technology Process of diethyl N-[4-[2-(2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-ylmethyl) methylamino]benzoyl]-L-glutamate

There total 4 articles about diethyl N-[4-[2-(2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-ylmethyl) methylamino]benzoyl]-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 76807-60-8
diethyl N-[4-[(2,4-diaminopyrido[3,2-d]pyrimidin-6-ylmethyl)methylamino]benzoyl]-L-glutamate

: 1383672-71-6
diethyl N-[4-[2-(2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-ylmethyl) methylamino]benzoyl]-L-glutamate

Guidance literature:: With platinum(IV) oxide; hydrogen; acetic acid; In ethanol; at 20 ℃; for 48h; under 3000.3 Torr;
DOI:10.1016/j.ejmech.2012.09.027

Reference yield:

: 76807-56-2
2,4-diamino-6-(bromomethyl)pyrido<3,2-d>pyrimidine

: 1383672-71-6
diethyl N-[4-[2-(2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-ylmethyl) methylamino]benzoyl]-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl acetamide / 2 h / 20 °C

2: platinum(IV) oxide; acetic acid; hydrogen / ethanol / 48 h / 20 °C / 3000.3 Torr

With platinum(IV) oxide; hydrogen; acetic acid; In ethanol; N,N-dimethyl acetamide;
DOI:10.1016/j.ejmech.2012.09.027

Reference yield:

: 76807-55-1
6-(Acetoxymethyl)-2,4-dichloropyrido<3,2-d>pyrimidine

: 1383672-71-6
diethyl N-[4-[2-(2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-ylmethyl) methylamino]benzoyl]-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1: ammonia / methanol / 150 °C / Sealed tube

2: phosphorus tribromide

3: N,N-dimethyl acetamide / 2 h / 20 °C

4: platinum(IV) oxide; acetic acid; hydrogen / ethanol / 48 h / 20 °C / 3000.3 Torr

With platinum(IV) oxide; ammonia; hydrogen; phosphorus tribromide; acetic acid; In methanol; ethanol; N,N-dimethyl acetamide;
DOI:10.1016/j.ejmech.2012.09.027