(S)-2-{N-benzyl-N-[(1-ethylpyrrolidin-2-yl)methyl]aminomethyl}-4,6-di-tert-butylphenol

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Chemical Name:(S)-2-{N-benzyl-N-[(1-ethylpyrrolidin-2-yl)methyl]aminomethyl}-4,6-di-tert-butylphenol
CAS No.:1454866-45-5
Molecular Formula:C₂₉H₄₄N₂O
Molecular Weight:436.681
Hs Code.:

Synonyms:(S)-2-{N-benzyl-N-[(1-ethylpyrrolidin-2-yl)methyl]aminomethyl}-4,6-di-tert-butylphenol

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Chemical Property of (S)-2-{N-benzyl-N-[(1-ethylpyrrolidin-2-yl)methyl]aminomethyl}-4,6-di-tert-butylphenol

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Technology Process of (S)-2-{N-benzyl-N-[(1-ethylpyrrolidin-2-yl)methyl]aminomethyl}-4,6-di-tert-butylphenol

There total 5 articles about (S)-2-{N-benzyl-N-[(1-ethylpyrrolidin-2-yl)methyl]aminomethyl}-4,6-di-tert-butylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.7%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 96-76-4
2,4-di-tert-Butylphenol

: 22795-99-9
(S)-2-(Aminomethyl)-1-ethylpyrrolidine

: 100-52-7
benzaldehyde

: 1454866-45-5
(S)-2-{N-benzyl-N-[(1-ethylpyrrolidin-2-yl)methyl]aminomethyl}-4,6-di-tert-butylphenol

Guidance literature:: (S)-2-(Aminomethyl)-1-ethylpyrrolidine; benzaldehyde; In ethanol; for 24h; Reflux;

With sodium tetrahydroborate; In ethanol; for 3h;

formaldehyd; 2,4-di-tert-Butylphenol; In ethanol; for 12h; Reflux;

Reference yield:

: C₁₄H₂₀N₂

: 1454866-45-5
(S)-2-{N-benzyl-N-[(1-ethylpyrrolidin-2-yl)methyl]aminomethyl}-4,6-di-tert-butylphenol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / 3 h / 60 °C / Inert atmosphere

2: ethanol / 12 h / 90 °C / Inert atmosphere

With sodium tetrahydroborate; In ethanol;
DOI:10.1039/c3cc44980g

Reference yield:

: 7531-52-4
L-prolinamide

: 1454866-45-5
(S)-2-{N-benzyl-N-[(1-ethylpyrrolidin-2-yl)methyl]aminomethyl}-4,6-di-tert-butylphenol

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / N,N-dimethyl-formamide / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere

3: ethanol / 24 h / Inert atmosphere; Reflux

4: sodium tetrahydroborate / ethanol / 3 h / 60 °C / Inert atmosphere

5: ethanol / 12 h / 90 °C / Inert atmosphere

With sodium tetrahydroborate; lithium aluminium tetrahydride; sodium hydrogencarbonate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1039/c3cc44980g