(R)-2-benzyloxy-1-((4S,5R)-5-((S)-2-(benzyloxy)-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl acetate

Base Information

Chemical Name:(R)-2-benzyloxy-1-((4S,5R)-5-((S)-2-(benzyloxy)-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl acetate
CAS No.:914982-60-8
Molecular Formula:C₃₂H₃₉NO₈S
Molecular Weight:597.73
Hs Code.:

Synonyms:(R)-2-benzyloxy-1-((4S,5R)-5-((S)-2-(benzyloxy)-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl acetate

Suppliers and Price of (R)-2-benzyloxy-1-((4S,5R)-5-((S)-2-(benzyloxy)-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-benzyloxy-1-((4S,5R)-5-((S)-2-(benzyloxy)-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl acetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-2-benzyloxy-1-((4S,5R)-5-((S)-2-(benzyloxy)-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl acetate

There total 9 articles about (R)-2-benzyloxy-1-((4S,5R)-5-((S)-2-(benzyloxy)-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 914982-59-5
Acetic acid (R)-1-[(4S,5R)-5-((S)-1-amino-2-benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-benzyloxy-ethyl ester

: 98-59-9
p-toluenesulfonyl chloride

: 914982-60-8
(R)-2-benzyloxy-1-((4S,5R)-5-((S)-2-(benzyloxy)-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl acetate

Guidance literature:: With pyridine; at 0 - 20 ℃; for 3h;
DOI:10.1016/j.tet.2006.08.035

Reference yield:

: 914982-58-4
(R)-1-((4S,5R)-5-((S)-1-azido-2-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(benzyloxy)ethyl acetate

: 914982-60-8
(R)-2-benzyloxy-1-((4S,5R)-5-((S)-2-(benzyloxy)-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / hydrogen / Lindlar's catalyst / methanol / 4 h / 20 °C / 760 Torr

2: 86 percent / pyridine / 3 h / 0 - 20 °C

With pyridine; hydrogen; Lindlar's catalyst; In methanol;
DOI:10.1016/j.tet.2006.08.035

Reference yield:

: 914982-57-3
Acetic acid (R)-2-benzyloxy-1-{(4R,5S)-5-[(R)-2-benzyloxy-1-(toluene-4-sulfonyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-ethyl ester

: 914982-60-8
(R)-2-benzyloxy-1-((4S,5R)-5-((S)-2-(benzyloxy)-1-(tosylamino)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / sodium azide / dimethylformamide / 24 h / 110 °C

2: 91 percent / hydrogen / Lindlar's catalyst / methanol / 4 h / 20 °C / 760 Torr

3: 86 percent / pyridine / 3 h / 0 - 20 °C

With pyridine; sodium azide; hydrogen; Lindlar's catalyst; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2006.08.035