(1S,2S,3R,5R)-2-(Benzyloxy)Methyl-6-oxabicyclo[3.1.0]hexan-3-ol

Base Information

Chemical Name:(1S,2S,3R,5R)-2-(Benzyloxy)Methyl-6-oxabicyclo[3.1.0]hexan-3-ol
CAS No.:1353742-19-4
Molecular Formula:C₁₃H₁₆O₃
Molecular Weight:220.268
Hs Code.:
Mol file:1353742-19-4.mol

Synonyms:(1S,2S,3R,5R)-2-((benzyloxy)methyl)-6-oxabicyclo[3.1.0]hexan-3-ol

Suppliers and Price of (1S,2S,3R,5R)-2-(Benzyloxy)Methyl-6-oxabicyclo[3.1.0]hexan-3-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(1S,2S,3R,5R)-2-(Benzyloxy)methyl-6-oxabicyclo[3.1.0]hexan-3-ol
10mg
$ 140.00

Medical Isotopes, Inc.
(1S,2S,3R,5R)-2-(Benzyloxy)methyl-6-oxabicyclo[3.1.0]hexan-3-ol
100 mg
$ 2000.00

Medical Isotopes, Inc.
(1S,2S,3R,5R)-2-(Benzyloxy)methyl-6-oxabicyclo[3.1.0]hexan-3-ol
10 mg
$ 625.00

American Custom Chemicals Corporation
(1S,2S,3R,5R)-2-(BENZYLOXY)METHYL-6-OXABICYCLO[3.1.0]HEXAN-3-OL 95.00%
5MG
$ 497.17

Total 3 raw suppliers

Chemical Property of (1S,2S,3R,5R)-2-(Benzyloxy)Methyl-6-oxabicyclo[3.1.0]hexan-3-ol

Chemical Property:

Solubility.:Dichloromethane, Diethyl Ether, Ethyl Acetate

Purity/Quality:

99% ^*data from raw suppliers

(1S,2S,3R,5R)-2-(Benzyloxy)methyl-6-oxabicyclo[3.1.0]hexan-3-ol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses ent-Entecavir (E558905) intermediate.

Technology Process of (1S,2S,3R,5R)-2-(Benzyloxy)Methyl-6-oxabicyclo[3.1.0]hexan-3-ol

There total 5 articles about (1S,2S,3R,5R)-2-(Benzyloxy)Methyl-6-oxabicyclo[3.1.0]hexan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 188399-48-6
(1R,2S)-2-((benzyloxy)methyl)cyclopent-3-en-1-ol

: 1353742-19-4
(1S,2S,3R,5R)-2-((benzyloxy)methyl)-6-oxabicyclo[3.1.0]hexan-3-ol

: 701278-59-3
(1R,2S,3R,5S)-2-((benzyloxy)methyl)-6-oxabicyclo[3.1.0]hexan-3-ol

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water; at 0 - 20 ℃; for 6h; Inert atmosphere;
DOI:10.1021/ol203213f

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 1353742-19-4
(1S,2S,3R,5R)-2-((benzyloxy)methyl)-6-oxabicyclo[3.1.0]hexan-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran; N,N-dimethyl-formamide / 0.33 h / -40 °C / Inert atmosphere

2.1: (+)-diisopinocampheylboron / tetrahydrofuran / -78 - -10 °C / Inert atmosphere

2.2: 24 h / 20 °C / Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane; water / 6 h / 0 - 20 °C / Inert atmosphere

With (+)-diisopinocampheylboron; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ol203213f

Reference yield:

: 39939-07-6
5-(benzyloxymethyl)cyclopentadiene

: 1353742-19-4
(1S,2S,3R,5R)-2-((benzyloxy)methyl)-6-oxabicyclo[3.1.0]hexan-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: (+)-diisopinocampheylboron / tetrahydrofuran / -78 - -10 °C / Inert atmosphere

1.2: 24 h / 20 °C / Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane; water / 6 h / 0 - 20 °C / Inert atmosphere

With (+)-diisopinocampheylboron; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ol203213f