(2-chloro-4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)(pyridin-3-yl)methanol

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Chemical Name:(2-chloro-4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)(pyridin-3-yl)methanol
CAS No.:1616372-17-8
Molecular Formula:C₂₅H₂₅Cl₂N₅O
Molecular Weight:482.412
Hs Code.:

Synonyms:(2-chloro-4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)(pyridin-3-yl)methanol

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Chemical Property of (2-chloro-4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)(pyridin-3-yl)methanol

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Technology Process of (2-chloro-4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)(pyridin-3-yl)methanol

There total 6 articles about (2-chloro-4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)(pyridin-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 626-55-1,163928-56-1
3-Bromopyridine

: 1616372-16-7
2-chloro-4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carbaldehyde

: 1616372-17-8
(2-chloro-4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)(pyridin-3-yl)methanol

Guidance literature:: 3-Bromopyridine; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 1h; Inert atmosphere;

2-chloro-4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carbaldehyde; In tetrahydrofuran; diethyl ether; hexane; at -78 ℃;

Reference yield:

: 934-67-8,4331-54-8,13064-83-0
trans-4-methylcyclohexanecarboxylic acid

: 1616372-17-8
(2-chloro-4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)(pyridin-3-yl)methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: borane-THF / tetrahydrofuran / 9 h / 0 - 25 °C / Inert atmosphere

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 13 h / 0 - 25 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 20 h / 100 °C

4.1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.25 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

5.1: trichlorophosphate / 16.5 h / 0 - 60 °C / Inert atmosphere

6.1: n-butyllithium / diethyl ether; hexane / 1 h / -78 °C / Inert atmosphere

6.2: -78 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; n-butyllithium; borane-THF; carbon tetrabromide; sodium hydride; sodium carbonate; triphenylphosphine; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 3937-49-3
(trans-4-methylcyclohexyl)methanol

: 1616372-17-8
(2-chloro-4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)(pyridin-3-yl)methanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 13 h / 0 - 25 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 20 h / 100 °C

3.1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.25 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

4.1: trichlorophosphate / 16.5 h / 0 - 60 °C / Inert atmosphere

5.1: n-butyllithium / diethyl ether; hexane / 1 h / -78 °C / Inert atmosphere

5.2: -78 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; n-butyllithium; carbon tetrabromide; sodium hydride; sodium carbonate; triphenylphosphine; trichlorophosphate; In 1,4-dioxane; diethyl ether; hexane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;