2-chloro-4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carbaldehyde

Base Information

Chemical Name:2-chloro-4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carbaldehyde
CAS No.:1616372-16-7
Molecular Formula:C₂₀H₂₀Cl₂N₄O
Molecular Weight:403.311
Hs Code.:

Synonyms:2-chloro-4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carbaldehyde

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Chemical Property of 2-chloro-4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carbaldehyde

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Technology Process of 2-chloro-4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carbaldehyde

There total 5 articles about 2-chloro-4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616372-01-0
2-chloro-4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1616372-16-7
2-chloro-4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carbaldehyde

Guidance literature:: With trichlorophosphate; at 0 - 60 ℃; for 16.5h; Inert atmosphere;

Reference yield:

: 3937-49-3
(trans-4-methylcyclohexyl)methanol

: 1616372-16-7
2-chloro-4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 13 h / 0 - 25 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 20 h / 100 °C

3.1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.25 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

4.1: trichlorophosphate / 16.5 h / 0 - 60 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; carbon tetrabromide; sodium hydride; sodium carbonate; triphenylphosphine; trichlorophosphate; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 934-67-8,4331-54-8,13064-83-0
trans-4-methylcyclohexanecarboxylic acid

: 1616372-16-7
2-chloro-4-(5-chloropyridin-3-yl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: borane-THF / tetrahydrofuran / 9 h / 0 - 25 °C / Inert atmosphere

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 13 h / 0 - 25 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 20 h / 100 °C

4.1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.25 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

5.1: trichlorophosphate / 16.5 h / 0 - 60 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; borane-THF; carbon tetrabromide; sodium hydride; sodium carbonate; triphenylphosphine; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;