Technology Process of 1-(benzenesulfonyl)-2-(2-pyridyl)-7-azaindole
There total 3 articles about 1-(benzenesulfonyl)-2-(2-pyridyl)-7-azaindole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridine;
With
lithium diisopropyl amide;
In
tetrahydrofuran; cyclohexane;
at 0 ℃;
for 0.5h;
With
zinc(II) chloride;
In
tetrahydrofuran; cyclohexane;
at 20 ℃;
for 0.5h;
2-bromo-pyridine;
With
bis-triphenylphosphine-palladium(II) chloride; diisobutylaluminium hydride;
In
tetrahydrofuran; hexane; cyclohexane;
for 6h;
Further stages.;
Heating;
DOI:10.1021/ja9944249
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 87 percent / aq. NaOH; tetrabutylammonium bromide / benzene / 2 h / 20 °C
2.1: LDA / tetrahydrofuran; cyclohexane / 0.5 h / 0 °C
2.2: ZnCl2 / tetrahydrofuran; cyclohexane / 0.5 h / 20 °C
2.3: 92 percent / Pd(PPh3)2Cl2; diisobutylaluminum hydride / hexane; tetrahydrofuran; cyclohexane / 6 h / Heating
With
sodium hydroxide; tetrabutylammomium bromide; lithium diisopropyl amide;
In
tetrahydrofuran; cyclohexane; benzene;
1.1: benzenesulfonylation / 2.1: Metallation / 2.2: ion metal exchange / 2.3: Arylation;
DOI:10.1021/ja9944249
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 87 percent / aq. NaOH; tetrabutylammonium bromide / benzene / 2 h / 20 °C
2.1: LDA / tetrahydrofuran; cyclohexane / 0.5 h / 0 °C
2.2: ZnCl2 / tetrahydrofuran; cyclohexane / 0.5 h / 20 °C
2.3: 92 percent / Pd(PPh3)2Cl2; diisobutylaluminum hydride / hexane; tetrahydrofuran; cyclohexane / 6 h / Heating
With
sodium hydroxide; tetrabutylammomium bromide; lithium diisopropyl amide;
In
tetrahydrofuran; cyclohexane; benzene;
1.1: benzenesulfonylation / 2.1: Metallation / 2.2: ion metal exchange / 2.3: Arylation;
DOI:10.1021/ja9944249