[2-(2-oxo-2-phenylethoxy)benzyl]triphenylphosphonium bromide

Base Information

• Chemical Name: [2-(2-oxo-2-phenylethoxy)benzyl]triphenylphosphonium bromide
• CAS No.: 109790-41-2
• Molecular Formula: Br*C₃₃H₂₈O₂P
• Molecular Weight: 567.462
• Mol file: 109790-41-2.mol

Synonyms:[2-(2-oxo-2-phenylethoxy)benzyl]triphenylphosphonium bromide

Chemical Property of [2-(2-oxo-2-phenylethoxy)benzyl]triphenylphosphonium bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [2-(2-oxo-2-phenylethoxy)benzyl]triphenylphosphonium bromide

There total 4 articles about [2-(2-oxo-2-phenylethoxy)benzyl]triphenylphosphonium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(o-hydroxymethylphenoxy)-1-phenylethanone (109790-47-8) + triphenylphosphine hydrobromide (6399-81-1) → [2-(2-oxo-2-phenylethoxy)benzyl]triphenylphosphonium bromide (109790-41-2)

Guidance literature:

In acetonitrile; at 90 ℃; for 3h;

DOI:10.1016/0223-5234(87)90005-5

Reference yield:

salicylic alcohol (90-01-7) → [2-(2-oxo-2-phenylethoxy)benzyl]triphenylphosphonium bromide (109790-41-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / K₂CO₃ / acetone / 3 h / 80 °C

2: 95 percent / acetonitrile / 3 h / 90 °C

With potassium carbonate; In acetone; acetonitrile;

DOI:10.1016/0223-5234(87)90005-5

Reference yield:

α-bromoacetophenone (70-11-1) → [2-(2-oxo-2-phenylethoxy)benzyl]triphenylphosphonium bromide (109790-41-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 20 °C / Inert atmosphere

2: acetonitrile / 90 °C / Inert atmosphere

With potassium carbonate; In acetone; acetonitrile;

DOI:10.1021/acs.orglett.7b02341

upstream raw materials:

2-(o-hydroxymethylphenoxy)-1-phenylethanone

triphenylphosphine hydrobromide

salicylic alcohol

α-bromoacetophenone

Downstream raw materials:

(S)-3-phenylchromane

Isoflavan

3-phenyl-2H-benzopyran