diethyl 1,4-dihydro-2-(2-hydroxy-2-methylpropyl)-6-methyl-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

Base Information

• Chemical Name: diethyl 1,4-dihydro-2-(2-hydroxy-2-methylpropyl)-6-methyl-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate
• CAS No.: 126179-79-1
• Molecular Formula: C₂₃H₂₈F₃NO₅
• Molecular Weight: 455.474
• Mol file: 126179-79-1.mol

Synonyms:diethyl 1,4-dihydro-2-(2-hydroxy-2-methylpropyl)-6-methyl-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

Chemical Property of diethyl 1,4-dihydro-2-(2-hydroxy-2-methylpropyl)-6-methyl-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 1,4-dihydro-2-(2-hydroxy-2-methylpropyl)-6-methyl-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

There total 3 articles about diethyl 1,4-dihydro-2-(2-hydroxy-2-methylpropyl)-6-methyl-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

C20H20F3LiNO4(1-)*Li(1+) + acetone (67-64-1) → ethyl 1,4,7,8-tetrahydro-2,7,7-trimethyl-5-oxo-4-<2-(trifluoromethyl)phenyl>-5H-pyrano<4,3-b>pyridine-3-carboxylate (126179-80-4) + diethyl 1,4-dihydro-2-(2-hydroxy-2-methylpropyl)-6-methyl-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate (126179-79-1)

Guidance literature:

Ambient temperature;

DOI:10.1016/S0040-4039(00)99253-0

Reference yield:

SKF 24260 (23191-75-5) → diethyl 1,4-dihydro-2-(2-hydroxy-2-methylpropyl)-6-methyl-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate (126179-79-1)

Guidance literature:

Multi-step reaction with 2 steps

1: n-butyl lithium / tetrahydrofuran / 0.5 h / -78 °C

2: Ambient temperature

With n-butyllithium; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)99253-0

Reference yield:

SKF 24260 (23191-75-5) + acetone (67-64-1) → ethyl 1,4,7,8-tetrahydro-2,7,7-trimethyl-5-oxo-4-<2-(trifluoromethyl)phenyl>-5H-pyrano<4,3-b>pyridine-3-carboxylate (126179-80-4) + diethyl 1,4-dihydro-2-(2-hydroxy-2-methylpropyl)-6-methyl-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate (126179-79-1)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, n-hexane, -78 deg C, 0.5 h, 2.) -78 deg C -> room temperature;

DOI:10.1021/jo00067a012

upstream raw materials:

SKF 24260

acetone