4-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid

Base Information

Chemical Name:4-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid
CAS No.:1455090-32-0
Molecular Formula:C₂₁H₁₇N₃O₆
Molecular Weight:407.382
Hs Code.:

Synonyms:4-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid

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Chemical Property of 4-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid

Chemical Property:

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Technology Process of 4-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid

There total 11 articles about 4-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1455094-84-4
4-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid methyl ester

: 1455090-32-0
4-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; ethanol; water; at 20 ℃; for 18h;

Reference yield:

: 1455091-04-9
2-(chloromethyl)-4-phenoxybenzoic acid methyl ester

: 1455090-32-0
4-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid

Guidance literature:: Multi-step reaction with 8 steps

1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 50 °C

2: sodium methylate / dimethyl sulfoxide; methanol / 0.5 h / 20 °C

3: sodium methylate / methanol / Reflux

4: sulfuric acid / water / 20 h / Reflux

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C

6: bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate / dichloromethane / 20 h / 20 °C

7: N,N-dimethyl-formamide / 0.1 h / 160 °C / Inert atmosphere

8: sodium hydroxide / tetrahydrofuran; water; ethanol / 18 h / 20 °C

With sulfuric acid; sodium methylate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium iodide; sodium hydroxide; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1455091-06-1
2-{[(methoxycarbonylmethyl)(toluene-4-sulfonyl)amino]methyl}-4-phenoxybenzoic acid methyl ester

: 1455090-32-0
4-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid

Guidance literature:: Multi-step reaction with 7 steps

1: sodium methylate / dimethyl sulfoxide; methanol / 0.5 h / 20 °C

2: sodium methylate / methanol / Reflux

3: sulfuric acid / water / 20 h / Reflux

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C

5: bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate / dichloromethane / 20 h / 20 °C

6: N,N-dimethyl-formamide / 0.1 h / 160 °C / Inert atmosphere

7: sodium hydroxide / tetrahydrofuran; water; ethanol / 18 h / 20 °C

With sulfuric acid; sodium methylate; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;