4-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid methyl ester

Base Information

Chemical Name:4-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid methyl ester
CAS No.:1455094-84-4
Molecular Formula:C₂₂H₁₉N₃O₆
Molecular Weight:421.409
Hs Code.:

Synonyms:4-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid methyl ester

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Chemical Property of 4-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid methyl ester

Chemical Property:

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Technology Process of 4-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid methyl ester

There total 10 articles about 4-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1455094-82-2
4-[(4-hydroxy-1-iodo-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid methyl ester

: copper(l) cyanide

: 1455094-84-4
4-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid methyl ester

Guidance literature:: In N,N-dimethyl-formamide; at 160 ℃; for 0.1h; Inert atmosphere;

Reference yield:

: 1455091-04-9
2-(chloromethyl)-4-phenoxybenzoic acid methyl ester

: 1455094-84-4
4-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 50 °C

2: sodium methylate / dimethyl sulfoxide; methanol / 0.5 h / 20 °C

3: sodium methylate / methanol / Reflux

4: sulfuric acid / water / 20 h / Reflux

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C

6: bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate / dichloromethane / 20 h / 20 °C

7: N,N-dimethyl-formamide / 0.1 h / 160 °C / Inert atmosphere

With sulfuric acid; sodium methylate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium iodide; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; In methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1455091-06-1
2-{[(methoxycarbonylmethyl)(toluene-4-sulfonyl)amino]methyl}-4-phenoxybenzoic acid methyl ester

: 1455094-84-4
4-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: sodium methylate / dimethyl sulfoxide; methanol / 0.5 h / 20 °C

2: sodium methylate / methanol / Reflux

3: sulfuric acid / water / 20 h / Reflux

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C

5: bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate / dichloromethane / 20 h / 20 °C

6: N,N-dimethyl-formamide / 0.1 h / 160 °C / Inert atmosphere

With sulfuric acid; sodium methylate; 3-chloro-benzenecarboperoxoic acid; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; In methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;