10-Chloro-2-(4'-chlorophenyl)-4,4a,5,6-tetrahydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one

Base Information

Chemical Name:10-Chloro-2-(4'-chlorophenyl)-4,4a,5,6-tetrahydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one
CAS No.:118258-13-2
Molecular Formula:C₁₈H₁₄Cl₂N₂OS
Molecular Weight:377.294
Hs Code.:

Synonyms:10-Chloro-2-(4'-chlorophenyl)-4,4a,5,6-tetrahydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one

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Chemical Property of 10-Chloro-2-(4'-chlorophenyl)-4,4a,5,6-tetrahydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one

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Technology Process of 10-Chloro-2-(4'-chlorophenyl)-4,4a,5,6-tetrahydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one

There total 5 articles about 10-Chloro-2-(4'-chlorophenyl)-4,4a,5,6-tetrahydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 118305-22-9
7-Chloro-5-oxo-2,3,4,5-tetrahydro-1-benzothiepin-4-acetic acid

: 118258-13-2
10-Chloro-2-(4'-chlorophenyl)-4,4a,5,6-tetrahydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one

Guidance literature:: With sodium acetate; In ethanol; Heating;
DOI:10.1248/cpb.39.2556

Reference yield:

: 30484-10-7
7-Chloro-2,3,4,5-tetrahydro-1-benzothiepin-5-one

: 118258-13-2
10-Chloro-2-(4'-chlorophenyl)-4,4a,5,6-tetrahydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one

Guidance literature:: Multi-step reaction with 5 steps

2: acetone / 3 h / Ambient temperature

3: methanol; H₂O / 1 h / Ambient temperature

4: conc. HCl, AcOH / 3 h / Heating

5: 66 percent / NaOAc / ethanol / Heating

With hydrogenchloride; sodium acetate; acetic acid; In methanol; ethanol; water; acetone;
DOI:10.1248/cpb.39.2556

Reference yield:

: 7-Chloro-5-oxo-2,3,4,5-tetrahydro-1-benzothiepin-4-acetonitrile

: 118258-13-2
10-Chloro-2-(4'-chlorophenyl)-4,4a,5,6-tetrahydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: conc. HCl, AcOH / 3 h / Heating

2: 66 percent / NaOAc / ethanol / Heating

With hydrogenchloride; sodium acetate; acetic acid; In ethanol;
DOI:10.1248/cpb.39.2556