Hydron;4-[3-(trifluoromethyl)phenyl]piperidin-4-ol;chloride

Base Information

• Chemical Name: Hydron;4-[3-(trifluoromethyl)phenyl]piperidin-4-ol;chloride
• CAS No.: 1683-49-4
• Molecular Formula: C₁₂H₁₄F₃NO*ClH
• Molecular Weight: 281.705
• Hs Code.: 2933399090
• Mol file: 1683-49-4.mol

Synonyms:SCHEMBL23411250;hydron;4-[3-(trifluoromethyl)phenyl]piperidin-4-ol;chloride

Chemical Property of Hydron;4-[3-(trifluoromethyl)phenyl]piperidin-4-ol;chloride

Chemical Property:

• Vapor Pressure: 0.000456mmHg at 25°C
• Melting Point: 190-196 °C
• Refractive Index: 1,496
• Boiling Point: 301.8°Cat760mmHg
• Flash Point: 136.3°C
• PSA: 32.26000
• Density: 1.253g/cm³
• LogP: 3.40720
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 1
• Exact Mass: 281.0794263
• Heavy Atom Count: 18
• Complexity: 261

Purity/Quality:

98%min ^*data from raw suppliers

4-[3-(Trifluoromethyl)phenyl]piperidin-4-olhydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 36/37/38-22-20/21/22
• Safety Statements: 37/39-26-36

MSDS Files:

Useful:

• Canonical SMILES: [H+].C1CNCCC1(C2=CC(=CC=C2)C(F)(F)F)O.[Cl-]

Technology Process of Hydron;4-[3-(trifluoromethyl)phenyl]piperidin-4-ol;chloride

There total 3 articles about Hydron;4-[3-(trifluoromethyl)phenyl]piperidin-4-ol;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Benzyl-4-[3-(trifluoromethyl)phenyl]-4-piperidinol hydrochloride (1535-28-0) → 4-hydroxy-4-(3-trifluoromethylphenyl)piperidine hydrochloride (1683-49-4)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; ethanol; at 50 ℃; under 1500.15 Torr;

Reference yield:

4-(3-trifluoromethyl-phenyl)-piperidine hydrochloride (6652-16-0) + 7-(2,3-epoxypropoxy)-2,3-dihydro-2,2-dimethylbenzofuran (250289-99-7) → 4-hydroxy-4-(3-trifluoromethylphenyl)piperidine hydrochloride (1683-49-4)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In ethanol; dichloromethane; water;

Reference yield:

→ 4-hydroxy-4-(3-trifluoromethylphenyl)piperidine hydrochloride (1683-49-4)

Guidance literature:

upstream raw materials:

1-Benzyl-4-[3-(trifluoromethyl)phenyl]-4-piperidinol hydrochloride

4-(3-trifluoromethyl-phenyl)-piperidine hydrochloride

7-(2,3-epoxypropoxy)-2,3-dihydro-2,2-dimethylbenzofuran

Refernces

• 1、 -. "Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof". Page/Page column 9-10. . Retrieved 2008/06/13.