4-(3-TRIFLUOROMETHYLPHENYL)PIPERIDINE HYDROCHLORIDE

Base Information

• Chemical Name: 4-(3-TRIFLUOROMETHYLPHENYL)PIPERIDINE HYDROCHLORIDE
• CAS No.: 6652-16-0
• Molecular Formula: C12H14F3N^.HCl
• Molecular Weight: 265.706
• Hs Code.: 2933399090
• Mol file: 6652-16-0.mol

Synonyms:Piperidine,4-(a,a,a-trifluoro-m-tolyl)-, hydrochloride (7CI,8CI);Piperidine, 4-[3-(trifluoromethyl)phenyl]-,hydrochloride (9CI);4-(3-Trifluoromethylphenyl)piperidine hydrochloride;4-[3-(Trifluoromethyl)phenyl]piperidine HCl;

Chemical Property of 4-(3-TRIFLUOROMETHYLPHENYL)PIPERIDINE HYDROCHLORIDE

Chemical Property:

• Melting Point: 206-208 °C
• PSA: 12.03000
• LogP: 4.30320
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

4-[3-(Trifluoromethyl)phenyl]piperidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 22-36-52
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3-TRIFLUOROMETHYLPHENYL)PIPERIDINE HYDROCHLORIDE

There total 7 articles about 4-(3-TRIFLUOROMETHYLPHENYL)PIPERIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

C19H18F3N*ClH (84447-17-6) → 4-(3-trifluoromethyl-phenyl)-piperidine hydrochloride (6652-16-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; for 60h;

DOI:10.1016/j.bmcl.2012.01.122

Reference yield:

4-(3-trifluoromethylphenyl)-4-hydroxy piperidine (2249-28-7) + 7-(2,3-epoxypropoxy)-2,3-dihydro-2,2-dimethylbenzofuran (250289-99-7) → 4-(3-trifluoromethyl-phenyl)-piperidine hydrochloride (6652-16-0)

Guidance literature:

With hydrogenchloride; hydrogen; palladium/carbon catalyst; In ethanol;

Reference yield:

1-benzyl-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine (346688-68-4) → 4-(3-trifluoromethyl-phenyl)-piperidine hydrochloride (6652-16-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / diethyl ether; ethyl acetate

2: palladium 10% on activated carbon; hydrogen / ethanol / 60 h

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In diethyl ether; ethanol; ethyl acetate;

DOI:10.1016/j.bmcl.2012.01.122

upstream raw materials:

4-(3-trifluoromethylphenyl)-4-hydroxy piperidine

7-(2,3-epoxypropoxy)-2,3-dihydro-2,2-dimethylbenzofuran

1-phenylmethyl-4-piperidone

1-benzyl-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine

Downstream raw materials:

4-hydroxy-4-(3-trifluoromethylphenyl)piperidine hydrochloride

5'-nitro-4-(3-trifluoromethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl

2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid [4-(3-trifluoromethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-yl]-amide

4-(3-trifluoromethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-ylamine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 6652-16-0 4-(3-TRIFLUOROMETHYLPHENYL)PIPERIDINE HYDROCHLORIDE

Send

Send

Metric Ton KG G Pound L ML

Send

Send