6652-16-0

Usage

Uses

Used in Organic Synthesis:
4-(3-Trifluoromethylphenyl)piperidine hydrochloride is used as a reagent in organic synthesis for its ability to participate in a range of chemical reactions, facilitating the creation of new compounds with potential applications in various industries.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-(3-Trifluoromethylphenyl)piperidine hydrochloride serves as a key intermediate in the development of new medications. Its interactions with biological systems make it a promising candidate for the creation of drugs targeting specific biological pathways or receptors.
Used in Laboratory Settings:
Due to its increased solubility in water, 4-(3-Trifluoromethylphenyl)piperidine hydrochloride is used as a convenient compound for laboratory work, where its easy handling and use in aqueous solutions are beneficial for a variety of experimental procedures and analyses.

InChI:InChI=1/C12H14F3N.ClH/c13-12(14,15)11-3-1-2-10(8-11)9-4-6-16-7-5-9;/h1-3,8-9,16H,4-7H2;1H

Upstream product

• 56108-27-1 1-benzyl-4-(3-trifluoromethylphenyl)piperidin-4-ol 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 84447-17-6 C₁₉H₁₈F₃N*ClH 
• 346688-68-4 1-benzyl-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 2249-28-7 4-(3-trifluoromethylphenyl)-4-hydroxy piperidine 
• 250289-99-7 7-(2,3-epoxypropoxy)-2,3-dihydro-2,2-dimethylbenzofuran 

Downstream Products

• 1683-49-4 4-hydroxy-4-(3-trifluoromethylphenyl)piperidine hydrochloride 
• 1229418-79-4 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid [4-(3-trifluoromethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-yl]-amide 
• 1229419-19-5 4-(3-trifluoromethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-ylamine 
• 1224869-59-3 4-(3-trifluoromethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-carboxylic acid (5-methyl-4-phenyl-thiazol-2-yl)-amide 
• 1229419-20-8 5'-nitro-4-(3-trifluoromethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl 

Relevant academic research and scientific papers

Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6- tetrahydropyridines as 5-HT2C agonists

A series of substituted 4-arylpiperidines and a smaller family of 4-aryl-1,2,3,6-tetrahydropyridines were synthesized and their biological activity at the 5-HT2C receptor studied to determine whether either series showed noteworthy agonist activity. Structure-activity relationships were developed from the performed receptor binding assays and functional studies, and the results of the analysis are presented herein.

AZABENZIMIDAZOLYL COMPOUNDS

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I), as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Modulators of dopamine neurotransmission

A 3-substituted 4-(phenyl-N-alkyl)-piperazine compound of the following formula: wherein R1 is selected from the group consisting of OSO2CF3, OSO2CH3, SO2R3, COCF3, CO

Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient

The present invention is a piperazinylalkylbenzofuran derivative of the formula wherein R1 represents a C1-4 alkyl group, R2 stands for a hydrogen atom, X means an oxygen atom, Y is a hydroxyl group, Z represents a hydrogen atom, Ar′ represents a diphenylmethyl group, a pyridyl group, a partially saturated 5-membered heterocyclic group or a phenyl group, n has a value of 0 or 1, and pharmaceutically suitable acid addition salts thereof.