ethyl 4-(2-{(2S)-1-[(benzyloxy)carbonyl]piperidin-2-yl}-3H-imidazo[4,5-b]pyridin-3-yl)-L-phenylalaninate

Base Information

• Chemical Name: ethyl 4-(2-{(2S)-1-[(benzyloxy)carbonyl]piperidin-2-yl}-3H-imidazo[4,5-b]pyridin-3-yl)-L-phenylalaninate
• CAS No.: 1031339-39-5
• Molecular Formula: C₃₀H₃₃N₅O₄
• Molecular Weight: 527.623

Synonyms:ethyl 4-(2-{(2S)-1-[(benzyloxy)carbonyl]piperidin-2-yl}-3H-imidazo[4,5-b]pyridin-3-yl)-L-phenylalaninate

Chemical Property of ethyl 4-(2-{(2S)-1-[(benzyloxy)carbonyl]piperidin-2-yl}-3H-imidazo[4,5-b]pyridin-3-yl)-L-phenylalaninate

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Technology Process of ethyl 4-(2-{(2S)-1-[(benzyloxy)carbonyl]piperidin-2-yl}-3H-imidazo[4,5-b]pyridin-3-yl)-L-phenylalaninate

There total 1 articles about ethyl 4-(2-{(2S)-1-[(benzyloxy)carbonyl]piperidin-2-yl}-3H-imidazo[4,5-b]pyridin-3-yl)-L-phenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 4-(2-{(2S)-1-[(benzyloxy)carbonyl]piperidin-2-yl}-3H-imidazo[4,5-b]pyridin-3-yl)-N-(tert-butoxycarbonyl)-L-phenylalaninate (1031339-24-8) → ethyl 4-(2-{(2S)-1-[(benzyloxy)carbonyl]piperidin-2-yl}-3H-imidazo[4,5-b]pyridin-3-yl)-L-phenylalaninate (1031339-39-5)

Guidance literature:

ethyl 4-(2-{(2S)-1-[(benzyloxy)carbonyl]piperidin-2-yl}-3H-imidazo[4,5-b]pyridin-3-yl)-N-(tert-butoxycarbonyl)-L-phenylalaninate; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 20.1667h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield: 61.0%

ethyl 4-(2-{(2S)-1-[(benzyloxy)carbonyl]piperidin-2-yl}-3H-imidazo[4,5-b]pyridin-3-yl)-L-phenylalaninate (1031339-39-5) + 1-keto-3-hydroxy-spiro[3.5]non-2-ene (455264-97-8) → ethyl 4-(2-{(2S)-1-[(benzyloxy)carbonyl]piperidin-2-yl}-3H-imidazo[4,5-b]pyridin-3-yl)-N-(3-oxospiro[3.5]non-1-en-1-yl)-L-phenylalaninate (1031339-43-1)

Guidance literature:

In ethyl acetate; at 80 ℃; for 18h;

Reference yield: 47.0%

ethyl 4-(2-{(2S)-1-[(benzyloxy)carbonyl]piperidin-2-yl}-3H-imidazo[4,5-b]pyridin-3-yl)-L-phenylalaninate (1031339-39-5) + 3,5-dichloroisonicotinoyl chloride (229328-97-6) → ethyl 4-(2-{(2S)-1-[(benzyloxy)carbonyl]piperidin-2-yl}-3H-imidazo[4,5-b]pyridin-3-yl)-N-(3,5-dichloroisonicotinoyl)-L-phenylalaninate (1031341-80-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 18h;

upstream raw materials:

ethyl 4-(2-{(2S)-1-[(benzyloxy)carbonyl]piperidin-2-yl}-3H-imidazo[4,5-b]pyridin-3-yl)-N-(tert-butoxycarbonyl)-L-phenylalaninate

Downstream raw materials:

ethyl 4-(2-{(2S)-1-[(benzyloxy)carbonyl]piperidin-2-yl}-3H-imidazo[4,5-b]pyridin-3-yl)-N-(3,5-dichloroisonicotinoyl)-L-phenylalaninate

ethyl 4-(2-{(2S)-1-[(benzyloxy)carbonyl]piperidin-2-yl}-3H-imidazo[4,5-b]pyridin-3-yl)-N-(3-oxospiro[3.5]non-1-en-1-yl)-L-phenylalaninate

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