4-(3-Pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-pyridine

Base Information

Chemical Name:4-(3-Pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-pyridine
CAS No.:452343-22-5
Molecular Formula:C₄₄H₃₉N₅O
Molecular Weight:653.827
Hs Code.:

Synonyms:4-(3-Pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-pyridine

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Chemical Property of 4-(3-Pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-pyridine

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Technology Process of 4-(3-Pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-pyridine

There total 7 articles about 4-(3-Pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 452343-10-1
2-(4-hydroxyphenyl)-4-(3-pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)pyridine

: 7250-67-1
1-(2-chloroethyl)pyrrolidine hydrochloride

: 452343-22-5
4-(3-Pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-pyridine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃;
DOI:10.1021/jm0509905

Reference yield:

: 446852-65-9
2-(2-bromopyridin-4-yl)-1-(pyridin-2-yl)ethan-1-one

: 452343-22-5
4-(3-Pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / dimethylformamide / 1.3 h / 20 °C

2: 45.8 g / hydrazine monohydrate / dimethylformamide / 2 h / 50 °C

3: 85.3 percent / potassium carbonate / acetone / 24 h / Heating

4: 91 percent / aq. Na₂CO₃; tetrakis(triphenylphosphine)palladium / ethanol; toluene / 2 h / Heating

5: potassium carbonate / dimethylformamide / 50 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; hydrazine hydrate; acetic acid; In ethanol; N,N-dimethyl-formamide; acetone; toluene; 4: Suzuki coupling;
DOI:10.1021/jm0509905

Reference yield:

: 446880-81-5
2-bromo-4-(3-(pyridine-2-yl)-1H-pyrazol-4-yl)pyridine

: 452343-22-5
4-(3-Pyridin-2-yl-1-trityl-1H-pyrazol-4-yl)-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 85.3 percent / potassium carbonate / acetone / 24 h / Heating

2: 91 percent / aq. Na₂CO₃; tetrakis(triphenylphosphine)palladium / ethanol; toluene / 2 h / Heating

3: potassium carbonate / dimethylformamide / 50 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; In ethanol; N,N-dimethyl-formamide; acetone; toluene; 2: Suzuki coupling;
DOI:10.1021/jm0509905