Chemical Property of Ergothioneine
Chemical Property:
- Appearance/Colour:White solid
- Melting Point:275-277 °C (dec.)
- Refractive Index:1.6740 (estimate)
- PSA：100.97000
- Density:1.2541 (rough estimate)
- LogP:0.77420
- Storage Temp.:−20°C
- Solubility.:Soluble in Water (up to 10 mg/ml)
- XLogP3:0.3
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:3
- Exact Mass:229.08849790
- Heavy Atom Count:15
- Complexity:314
- Purity/Quality:
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99% *data from raw suppliers
L-(+)-Ergothioneine *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C[N+](C)(C)C(CC1=CNC(=S)N1)C(=O)[O-]
- Isomeric SMILES:C[N+](C)(C)[C@@H](CC1=CNC(=S)N1)C(=O)[O-]
- Recent ClinicalTrials:Taxifolin/Ergothioneine and Immune Biomarkers in Healthy Volunteers (TaxEr)
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Description
L-(+)-Ergothioneine is a naturally-occurring amino acid derived from histidine via hercynine. Ergothioneine is a stable antioxidant that scavenges and detoxifies free radicals and oxidants, increases intracellular thiol levels, controls nuclear factor-κB activation, and inhibits inflammatory gene expression. In addition, it inhibits the peroxynitrite-dependent nitration of nitrotyrosine, blocks oxidative DNA damage and cell death, and prevents the formation of xanthine and hypoxanthine. Ergothioneine is transported by the organic cation/carnitine transporter 1, which has been linked with autoimmune diseases, including rheumatoid arthritis and Crohn’s disease.
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Uses
L-(+)-Ergothioneine is a natural molecule isolated from the rye ergot fungus and later identified in rat erythrocytes and liver and in numerous other animal tissues. Its antioxidizing properties may afford the compound therapeutic potential or it may be used as a food additive or in cosmetics.
