diethyl 4-(4-fluorophenyl)-2,6-diisopropyl-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

• Chemical Name: diethyl 4-(4-fluorophenyl)-2,6-diisopropyl-1,4-dihydropyridine-3,5-dicarboxylate
• CAS No.: 124863-78-1
• Molecular Formula: C₂₃H₃₀FNO₄
• Molecular Weight: 403.494
• Mol file: 124863-78-1.mol

Synonyms:diethyl 4-(4-fluorophenyl)-2,6-diisopropyl-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property of diethyl 4-(4-fluorophenyl)-2,6-diisopropyl-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 4-(4-fluorophenyl)-2,6-diisopropyl-1,4-dihydropyridine-3,5-dicarboxylate

There total 5 articles about diethyl 4-(4-fluorophenyl)-2,6-diisopropyl-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.3%

ethyl (2E)-3-amino-4-methyl-2-pentenoate (372120-74-6) + (E)-2-<(4-fluorophenyl)methylene>-4-methyl-3-oxopentanoic acid ethyl ester (122930-45-4) → diethyl 4-(4-fluorophenyl)-2,6-diisopropyl-1,4-dihydropyridine-3,5-dicarboxylate (124863-78-1)

Guidance literature:

In ethanol; for 16.5h; Heating;

DOI:10.1002/jlcr.1050

Reference yield:

ethyl isobutyryl acetate + 4-fluorobenzaldehyde (459-57-4) + Ethyl 3-amino-4-methyl-2-pentenoate (70106-45-5) → diethyl 4-(4-fluorophenyl)-2,6-diisopropyl-1,4-dihydropyridine-3,5-dicarboxylate (124863-78-1)

Guidance literature:

Reference yield:

4-fluorobenzaldehyde (459-57-4) → diethyl 4-(4-fluorophenyl)-2,6-diisopropyl-1,4-dihydropyridine-3,5-dicarboxylate (124863-78-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / pyperidine; acetic acid / propan-2-ol / 22 h / 20 °C

2: 60.3 percent / ethanol / 16.5 h / Heating

With piperidine; acetic acid; In ethanol; isopropyl alcohol;

DOI:10.1002/jlcr.1050

upstream raw materials:

ethyl (2E)-3-amino-4-methyl-2-pentenoate

(E)-2-<(4-fluorophenyl)methylene>-4-methyl-3-oxopentanoic acid ethyl ester

4-fluorobenzaldehyde

ethyl 4-methyl-3-oxo-pentanoate

Downstream raw materials:

diethyl 4-(4-fluorophenyl)-2,6-diisopropylpyridine-3,5-dicarboxylate

ethyl 4-(4-fluorophenyl)-5-(hydroxymethyl)-2,6-diisopropylnicotinate

tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-2,6-diisopropyl-5-[(d3-methoxy)methyl]pyridin-3-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

(4R,6S,E)-6-(2-(4-(4-fluorophenyl)-2,6-diisopropyl-5-[(d3-methoxy)methyl]-pyridin-3-yl)vinyl)-4-hydroxy-tetrahydropyran-2-one