2-Pentenoic acid, 3-amino-4-methyl-, ethyl ester

Base Information

• Chemical Name: 2-Pentenoic acid, 3-amino-4-methyl-, ethyl ester
• CAS No.: 70106-45-5
• Molecular Formula: C8H15NO2
• Molecular Weight: 157.213
• Hs Code.: 2922499990
• Mol file: 70106-45-5.mol

Synonyms:2-Pentenoic acid, 3-amino-4-methyl-, ethyl ester;3-Amino-4-methyl-2-pentenoicacidethylester

Chemical Property of 2-Pentenoic acid, 3-amino-4-methyl-, ethyl ester

Chemical Property:

• Vapor Pressure: 0.035mmHg at 25°C
• Boiling Point: 242.014°C at 760 mmHg
• Flash Point: 107.297°C
• PSA: 52.32000
• Density: 0.973g/cm³
• LogP: 1.74840

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pentenoic acid, 3-amino-4-methyl-, ethyl ester

There total 5 articles about 2-Pentenoic acid, 3-amino-4-methyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.6%

ethyl 4-methyl-3-oxo-pentanoate (7152-15-0) → Ethyl 3-amino-4-methyl-2-pentenoate (70106-45-5)

Guidance literature:

With ammonium acetate; acetic acid; In water; toluene; Reflux;

Reference yield: 83.0%

(Z)-3-Ethoxycarbonylamino-4-methyl-pent-2-enoic acid ethyl ester → Ethyl 3-amino-4-methyl-2-pentenoate (70106-45-5)

Guidance literature:

With sodium ethanolate; In ethanol; for 18h; Heating;

Reference yield:

Isobutyronitrile (78-82-0) + ethyl bromoacetate (105-36-2) → Ethyl 3-amino-4-methyl-2-pentenoate (70106-45-5)

Guidance literature:

Isobutyronitrile; ethyl bromoacetate; With methanesulfonic acid; zinc; In tetrahydrofuran; for 3h; Reflux; Inert atmosphere;

With water; potassium carbonate; In ethyl acetate; for 0.5h;

DOI:10.1002/ejoc.201701472

upstream raw materials:

ethanol

5-(1-Amino-2-methyl-propylidene)-2,2-dimethyl-[1,3]dioxane-4,6-dione

ethyl 4-methyl-3-oxo-pentanoate

Isobutyronitrile

Downstream raw materials:

ethyl 2-isopropylnicotinate

diethyl 4-(4-fluorophenyl)-2,6-diisopropyl-1,4-dihydropyridine-3,5-dicarboxylate