2-bromo-5-chloro-4-(4-ethoxybenzyl)phenol

Base Information

Chemical Name:2-bromo-5-chloro-4-(4-ethoxybenzyl)phenol
CAS No.:1338728-11-2
Molecular Formula:C₁₅H₁₄BrClO₂
Molecular Weight:341.632
Hs Code.:

Synonyms:2-bromo-5-chloro-4-(4-ethoxybenzyl)phenol

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Chemical Property of 2-bromo-5-chloro-4-(4-ethoxybenzyl)phenol

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Technology Process of 2-bromo-5-chloro-4-(4-ethoxybenzyl)phenol

There total 7 articles about 2-bromo-5-chloro-4-(4-ethoxybenzyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-bromo-4-chloro-5-(4-ethoxybenzyl)-2-methoxybenzen

: 1338728-11-2
2-bromo-5-chloro-4-(4-ethoxybenzyl)phenol

Guidance literature:: 1-bromo-4-chloro-5-(4-ethoxybenzyl)-2-methoxybenzen; With sodium thioethylate; In N,N-dimethyl-formamide; at 90 ℃; for 3h; Inert atmosphere;

With hydrogenchloride; In water; N,N-dimethyl-formamide; at 0 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2011.07.045

Reference yield:

: 1259020-46-6
5-bromo-2-chloro-4-hydroxybenzonitrile

: 1338728-11-2
2-bromo-5-chloro-4-(4-ethoxybenzyl)phenol

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hydroxide monohydrate / tetrahydrofuran / 5 h / 75 °C / Inert atmosphere

2.1: water; sodium hydroxide / ethanol / 100 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

3.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 4 h / 90 °C / Inert atmosphere

4.1: aluminum (III) chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

5.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / 2 h / -10 - 0 °C / Inert atmosphere

6.1: sodium thioethylate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

6.2: 0 °C / Inert atmosphere

With triethylsilane; aluminum (III) chloride; thionyl chloride; lithium hydroxide monohydrate; boron trifluoride diethyl etherate; water; N,N-dimethyl-formamide; sodium hydroxide; sodium thioethylate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.bmc.2011.07.045

Reference yield:

: 1259020-79-5
5-bromo-2-chloro-4-methoxybenzonitrile

: 1338728-11-2
2-bromo-5-chloro-4-(4-ethoxybenzyl)phenol

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; sodium hydroxide / ethanol / 100 °C / Inert atmosphere

1.2: 0 °C / Inert atmosphere

2.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 4 h / 90 °C / Inert atmosphere

3.1: aluminum (III) chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / 2 h / -10 - 0 °C / Inert atmosphere

5.1: sodium thioethylate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

5.2: 0 °C / Inert atmosphere

With triethylsilane; aluminum (III) chloride; thionyl chloride; boron trifluoride diethyl etherate; water; N,N-dimethyl-formamide; sodium hydroxide; sodium thioethylate; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.bmc.2011.07.045